Publications by authors named "Graham P"

Visual navigation is a key capability for robots and animals. Inspired by the navigational prowess of social insects, a family of insect-inspired route navigation algorithms-familiarity-based algorithms-have been developed that use stored panoramic images collected during a training route to subsequently derive directional information during route recapitulation. However, unlike the ants that inspire them, these algorithms ignore the sequence in which the training images are acquired so that all temporal information/correlation is lost.

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Purpose: The Falls After Stroke Trial (FAST) intervention involves habit-forming functional exercise and mobility practice which may increase physical activity. This substudy of FAST explores physical activity in community-dwelling people after stroke comparing the FAST intervention to usual care.

Methods: This study used a subset of 49 participants from a randomised trial.

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  • The study investigates the role of the nondominant temporal lobe in memory by comparing a spatial memory task (Brown Location Test, BLT) with verbal and visual memory tasks in patients with temporal lobe epilepsy (TLE).
  • Results showed that patients with right TLE specifically struggled with the BLT, while those with left TLE had difficulties with both verbal and nonverbal tasks.
  • Combining BLT Delayed Recall and Rey Auditory Verbal Learning Task (RAVLT) scores was found to be the best way to predict the lateralization of the epileptogenic zone, showing the importance of using diverse memory assessments for evaluating epilepsy surgery candidates.
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Introduction: The American Association of Endocrine Surgeons drafted Entrustable Professional Activities for Comprehensive Endocrine Surgery to assess trainees in core topics.

Methods: Fourteen Entrustable Professional Activities were defined. There were 10 "core" Entrustable Professional Activities, with 6 having 3 phases (pre-, intra-, and postoperative) and 4 having a single phase.

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Insect-inspired navigation strategies have the potential to unlock robotic navigation in power-constrained scenarios, as they can function effectively with limited computational resources. One such strategy, familiarity-based navigation, has successfully navigated a robot along routes of up to 60 m using a single-layer neural network trained with an Infomax learning rule. Given the small size of the network that effectively encodes the route, here we investigate the limits of this method, challenging it to navigate longer routes, investigating the relationship between performance, view acquisition rate and dimension, network size, and robustness to noise.

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Objective: To determine the diagnostic test accuracy of multiparametric magnetic resonance imaging (mpMRI) in detecting seminal vesicle invasion (SVI).

Methods: The Medical Literature Analysis and Retrieval System Online (MEDLINE), PubMed, the Excerpta Medica dataBASE (EMBASE) and Cochrane databases were search up to May 2023. We included studies that investigated the accuracy of mpMRI in detecting SVI when compared to radical prostatectomy specimens as the reference standard.

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Background: Education systems on an international basis have experienced an increase of neurodiverse students in mainstream schools. Such students can experience a deficit in school connectedness which restricts inclusive participation. In My Shoes is an intervention programme developed in Australia to support the inclusion of pupils with autism in primary school settings.

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  • Germline pathogenic variants in SDHB are linked to paraganglioma/pheochromocytoma syndrome type 4, but data on the clinical behavior of SDHB-associated pheochromocytomas (PCC) is limited.
  • A review of patients treated for SDHB-associated PCC revealed that 18% of SDHB-carriers had PCC, with a median diagnosis age of 40 years, and 25% presenting with distant metastasis.
  • The study indicates that SDHB-associated PCC tends to exhibit aggressive characteristics, with high recurrence rates and a significant percentage of patients remaining symptomatic despite treatment, highlighting the need for further research.
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  • The study looks at how risky behaviors in teenagers can affect their education later in life.
  • Researchers analyzed data from a group of young people and their parents over many years to see how things like smoking, drinking, and sex at a young age relate to finishing school.
  • Results showed that teens who waited longer to start smoking, drinking, or having sex tended to do better in school by the time they were 22.
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Background: Untreated hearing loss has an effect on cognition. It is hypothesized that the additional processing required to compensate for the sensory loss affects the cognitive resources available for other tasks and that this could be mitigated by a hearing device.

Methods: The impact on cognition of cochlear implants (CIs) was tested in 100 subjects, ≥60 years old, with bilateral moderately-severe to profound post linguistic deafness using hearing aids.

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Self-regulation, which encompasses cognitive, behavioural, and emotional domains, poses challenges in consistent measurement due to diverse definitions and conceptual complexities. In recognition of its profound impact on long-term mental health and wellbeing in children, this systematic review examined available self-regulation measures for children and young people between 1 and 18 years of age. The systematic review followed the COSMIN taxonomy and reported on the measurement tools' characteristics and psychometric properties.

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Microplastics are increasingly recognised as posing a significant environmental threat across systems. Their pervasive presence in freshwater poses a serious concern, given the heavy reliance of both humans and biodiversity on healthy, functioning freshwater ecosystems. Acknowledgment of the potential risks led the transboundary Orange-Senqu River Commission (ORASECOM) to include sampling for microlitter (primarily microplastics) in riverine sediment, surface water, and fishes, across Southern Africa as part of the third Joint Basin Survey (JBS3) in 2021.

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In response to communities where individuals experience both disproportionate numbers of Adverse childhood experiences (ACEs) and other health inequities, narrative change has emerged as a powerful tool to change how ACEs are viewed and addressed by communities. The special issue presents a set of papers examining efforts to use narrative change to address ACEs. In this commentary, we offer reflections on the introduction and three articles of the special issue and point to future considerations for implementation and impact of community narrative initiatives.

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  • - Taurine is a naturally occurring substance that plays a role in many bodily functions and may predict lung cancer development. Elevated levels of taurine were found in lung cancer patients, but the relationship between these levels and cancer progression is unclear.
  • - The study investigated taurine's impact on lung cancer using mouse models and patient tissue samples, aiming to find new treatment strategies by exploring taurine's mechanisms.
  • - Results showed that low doses of taurine and taurine drinks promoted tumor growth, while higher doses reduced this effect. The research suggests that taurine influences lung cancer progression through immune responses and inflammatory mechanisms, with related effects changing as patients age.
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The level of airway constriction in thin slices of lung tissue is highly variable. Owing to the labor-intensive nature of these experiments, determining the number of airways to be analyzed in order to allocate a reliable value of constriction in one mouse is challenging. Herein, a new automated device for physiology and image analysis was used to facilitate high throughput screening of airway constriction in lung slices.

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This article reports on promising pilot research which indicates that intergenerational musical practices in diverse First Nations families and communities in Vanuatu and Australia can shape cultural determinants of health (CDoH). We contend that such strength- and culture-based approaches to health promotion may help to disrupt colonial and deficit constructions of First Nations People and our health and wellbeing. The pilot study used Indigenist yarning which prioritized First Nations ideas, concepts, and knowledges during informal and relational semi-structured interviews with 9 diverse First Nations musicians in Australia and Vanuatu.

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Background And Objectives: The American Joint Committee on Cancer (AJCC) TNM staging system defines atypical parathyroid neoplasia (APN) as tumor in situ (Tis) and reserves the definition of parathyroid carcinoma (PC) to parathyroid tumor with invasion into surrounding structures. Because the parathyroid gland has no true capsule, "extension" with APN versus microscopic "invasion" of surrounding soft tissue can be difficult and confusing for clinicians. We aimed to determine the clinical course of atypical parathyroid neoplasm with and without soft tissue extension and parathyroid carcinoma with only soft tissue invasion (pT1) and to report the outcomes.

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The central complex of insects contains cells, organised as a ring attractor, that encode head direction. The 'bump' of activity in the ring can be updated by idiothetic cues and external sensory information. Plasticity at the synapses between these cells and the ring neurons, that are responsible for bringing sensory information into the central complex, has been proposed to form a mapping between visual cues and the heading estimate which allows for more accurate tracking of the current heading, than if only idiothetic information were used.

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Introduction: Neuropsychological assessment forms an integral part of the presurgical evaluation for patients with medically refractory focal epilepsy. Our understanding of cognitive impairment in epilepsy is based on seminal lesional studies that have demonstrated important structure-function relationships within the brain. However, a growing body of literature demonstrating heterogeneity in the cognitive profiles of patients with focal epilepsy (e.

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Objectives: To identify factors affecting functional hearing performance and quality of life (QoL) outcomes in paediatric cochlear implantation (CI) recipients at two University centres in mainland China.

Methods: Two university centres in mainland China, part of the prospective longitudinal Paediatric Implanted Recipient Observational Study (P-IROS), contributed participant data. Participants were aged under 10 years at time of CI.

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Conventional diagnostic tools for prostate cancer (PCa), such as prostate-specific antigen (PSA), transrectal ultrasound (TRUS), digital rectal examination (DRE), and tissue biopsy face, limitations in individual risk stratification due to invasiveness or reliability issues. Liquid biopsy is a less invasive and more accurate alternative. Metabolomic analysis of extracellular vesicles (EVs) holds a promise for detecting non-genetic alterations and biomarkers in PCa diagnosis and risk assessment.

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