A prospective comparison between cyclopentolate spray and drops in pediatric outpatients.

Purpose: To determine whether children tolerate cyclopentolate 1% spray better than drops and to assess the adequacy of cycloplegia achieved by spray for objective refraction.

Methods: The effects of cyclopentolate 1% drops and spray on distress levels were assessed prospectively using a guardian questionnaire in consecutive patients 10 years of age or younger. Distress was graded at various points during the appointment using a Likert scale of 1 to 10 (1 = no distress, 10 = severe distress).

Bilateral presumed ischemic optic neuropathy secondary to cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy.

Purpose: To report a case of bilateral ischemic optic neuropathy (ION) secondary to hypoperfusion of the optic nerve because of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy, an uncommon condition causing stepwise subcortical small vessel infarcts because of arterial wall rigidity, loss of autoregulation, and hypoperfusion.

Methods: We describe the ophthalmological presentation of this case including fluorescein angiography and kinetic perimetry.

Results: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy is an increasingly recognized condition with significant neurological sequelae.

Penetration of oral and topical ciprofloxacin into the aqueous humour.

Aims: To investigate the penetration of ciprofloxacin via different modes of administration into the aqueous humour using capillary zone electrophoresis and to determine its prophylactic role in ophthalmic surgery.

Methods: A prospective study was conducted of 84 patients, divided into two groups, undergoing routine cataract surgery and intraocular lens implantation. Forty patients received 750 mg ciprofloxacin orally the evening before and on the morning of surgery 12 h apart.