Publications by authors named "Graham Gumbert"
Article Synopsis
- The age of newly diagnosed breast tumors provides important insights into their causes and potential outcomes, as it reflects the time from when the tumor starts growing until it is detected.
- Researchers estimate this age using a novel method based on epigenetic changes rather than traditional age-related markers, revealing that younger tumors tend to be more aggressive with higher growth rates and instability.
- These findings highlight the potential of this epigenetic approach for better risk assessment and early detection of breast cancer by distinguishing between aggressive young tumors and older, more stable ones.
Ductal carcinoma in situ (DCIS) and invasive breast cancer share many morphologic, proteomic, and genomic alterations. Yet in contrast to invasive cancer, many DCIS tumors do not progress and may remain indolent over decades. To better understand the heterogenous nature of this disease, we reconstructed the growth dynamics of 18 DCIS tumors based on the geo-spatial distribution of their somatic mutations.
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