Chlorpromazine specifically prevents the wheel-induced feeding suppression in rats.

In rats, limited daytime wheel access suppresses feeding over the subsequent night [Lattanzio SB, Eikelboom R. Wheel access duration in rats: I. effects on feeding and running.

The effects of prior weight reduction on the running wheel-induced feeding suppression in rats.

Adult male rats given ad lib access to food and a running wheel show an initial feeding and weight suppression. Over 6-10 days feeding recovers, but body weight remains low. It is not clear which effect is primary, the wheel-induced feeding or weight change.