Publications by authors named "Graciele Domitila Tenani"
Background: Hepatocellular carcinoma (HCC) is the most common type of liver cancer. Risk factors for HCC include hepatitis C (HCV) and B (HBV) virus infection, alcoholic cirrhosis and genetic alterations that can affect several cellular pathways.
Objective: This study purposed to analyze the gene and serum protein expression of vascular endothelial growth factor (VEGF), angiogenesis, alpha fetoprotein, cystatin B (CSTB), β-catenin and glypican-3 (GPC3) in groups with HCC, cirrhosis or HCV and controls, and their relation with clinical staging in the HCC and cirrhosis groups, as well its sensitivity and specificity values.
Genetic polymorphisms related to the vitamin D pathway in patients with cirrhosis with or without hepatocellular carcinoma (HCC).
Ecancermedicalscience
May 2022
Article Synopsis
- The study investigates the genetic links between vitamin D transporter protein and cytochrome P450-24A1 in cirrhosis patients, both with and without hepatocellular carcinoma (HCC), analyzing their demographic, clinical, and biochemical profiles.
- A total of 383 individuals were categorized into three groups: patients with cirrhosis and HCC, patients with isolated cirrhosis, and a control group without liver disease, using genetic analysis methods like real-time PCR.
- Results indicated that specific genetic polymorphisms were more common in patients with HCC, highlighting factors such as advanced age, smoking, and diabetes as predictors for cirrhosis and HCC, while some genetic markers correlated with improved survival
Introduction: Cholangiocarcinoma (CCA) is the second most common type of primary liver cancer. Several factors, such as epigenetic changes in promoter genes, gene expression, and microRNAs (miR), can contribute to genomic instability in cancer. This study aimed at evaluating the expression of VEGF, miRs 145-3p, and 101-3p in patients with CCA and their potential as biomarkers for diagnosis and prognosis of CCA.
View Article and Find Full Text PDFHepatocellular carcinoma (HCC) is the most common primary neoplasia of the liver. Major risk factors for hepatocellular carcinoma include chronic liver diseases, carcinogenic agents, and genetic alterations as well as vascular endothelial growth factor (VEGF) involved in angiogenesis process. The aim of this study was to evaluate the association of (C936T and A1154G) with HCC and cirrhosis, in addition to serum levels of VEGF, clinical profile, lifestyle habits, and comorbidities.
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