Gastrointestinal bleeding as the first manifestation of a burned-out tumour of the testis.

We discuss the clinical presentation and course of the disease of a 25-year-old male who had gastrointestinal (GIT) symptoms secondary to retroperitoneal lymph node proliferation of a germ-cell tumour of the testis. The pathology evaluation of the orchiectomy specimen classified it as a burned-out tumour of the testis, given the lack of tumour elements and the presence of typical scarring tissue. Biological is-sues leading to tumour regression are discussed, as well.

Hereditary breast cancer associated with a germline BRCA2 mutation in identical female twins with similar disease expression.

The relative contribution of heritable and nonheritable factors to disease expression in BRCA2 mutation carriers is largely unknown. This report describes a familial breast cancer syndrome in a pair of identical female twins. These twins showed an extremely high concordance in their clinical histories; both twins exhibited similar cancer-related risk factors, and developed breast cancer at the same age with the same disease stage and identical histological features.