Introduction: Mexico was the country to initiate massive vaccination with heptavalent pneumococcal conjugate vaccine (PCV-7) in children. There is no information regarding pneumococcal invasive disease (PID) in children before and after implementation of PCV-7 in Mexico or elsewhere in Latin America.
Methodology: During October 2005 to September 2010, active surveillance for pediatric PID was initiated at Tijuana General Hospital.