State-level disparities in cervical cancer prevention and outcomes in the U.S.: a modeling study.

Background: Despite HPV vaccines' availability for over a decade, coverage across the US varies. While some states have tried to increase HPV vaccination coverage, most model-based analyses focus on national impacts. We evaluated hypothetical changes in HPV vaccination coverage at the national and state levels for California, New York, and Texas using a mathematical model.

State-level disparities in cervical cancer prevention and outcomes in the U.S.: A modeling study.

Background: Despite HPV vaccines' availability for over a decade, coverage across the US varies. While some states have tried to increase HPV vaccination coverage, most model-based analyses focus on national impacts. We evaluated hypothetical changes in HPV vaccination coverage at the national and state levels for California, New York, and Texas using a mathematical model.

The Use of Artificial Intelligence for Skin Disease Diagnosis in Primary Care Settings: A Systematic Review.

The prevalence of dermatological conditions in primary care, coupled with challenges such as dermatologist shortages and rising consultation costs, highlights the need for innovative solutions. Artificial intelligence (AI) holds promise for improving the diagnostic analysis of skin lesion images, potentially enhancing patient care in primary settings. This systematic review following PRISMA guidelines examined primary studies (2012-2022) assessing AI algorithms' diagnostic accuracy for skin diseases in primary care.

Influence of seagrass meadow length on beach morphodynamics: An experimental study.

A novel flume experiment was conducted to compare the sheltering effect of surrogate seagrass meadows of two different lengths against a bare beach (benchmark). The analyses focused on assessing the impact of meadow cross-shore extent on wave height attenuation, behaviour of wave orbital velocity components, sediment transport, and shoreline erosion. Throughout the tests conducted in the large-scale CIEM wave flume at LIM/UPC Barcelona, meadow density and submergence ratio remained constant, while irregular waves were run over an initial 1:15 sand beach profile.

A methodological framework for selecting an optimal sediment source within a littoral cell.

One of the most used measures to counteract coastal erosion is beach nourishment. It has advantages with respect to the use of rigid structures that sometimes entail non desired impacts on the surrounding areas. However, beach nourishments are often unsuccessful, requiring frequent refills due to the use of sediments that are not suitable.

How do Covid-19 policy options depend on end-of-year holiday contacts in Mexico City Metropolitan Area? A Modeling Study.

Background: With more than 20 million residents, Mexico City Metropolitan Area (MCMA) has the largest number of Covid-19 cases in Mexico and is at risk of exceeding its hospital capacity in late December 2020.

Methods: We used SC-COSMO, a dynamic compartmental Covid-19 model, to evaluate scenarios considering combinations of increased contacts during the holiday season, intensification of social distancing, and school reopening. Model parameters were derived from primary data from MCMA, published literature, and calibrated to time-series of incident confirmed cases, deaths, and hospital occupancy.

Managing coastal environments under climate change: Pathways to adaptation.

This paper deals with the question of how to manage vulnerable coastal systems so as to make them sustainable under present and future climates. This is interpreted in terms of the coastal functionality, mainly natural services and support for socio-economic activities. From here we discuss how to adapt for long term trends and for short terms episodic events using the DPSIR framework.

A simple description of age-related changes in crystalline lens thickness.

Purpose: An increase in lens thickness is often described as a linear function of age. However, contradictory opinions exist about whether the lens thickness continues to increase after 50 years of age. Differences in slope exist between this increase in younger and older people, but these findings are inconsistent with the linear behavior of an increase in the lens thickness throughout life.

Molecular basis of fish-eye disease in a patient from Spain. Characterization of a novel mutation in the LCAT gene and lipid analysis of the cornea.

The genetic and biochemical basis of fish-eye disease (FED) was investigated in a 63-year-old female proband with low plasma HDL cholesterol. Analyses of corneal and plasma lipids of the proband were consistent with impaired lecithin:cholesterol acyltransferase (LCAT) activity. Free cholesterol and phospholipid levels were elevated relative to control values, whereas cholesteryl ester levels were greatly reduced.

In vitro oxidised HDL exerts a cytotoxic effect on macrophages.

The cytotoxic effect of native high density lipoprotein (n-HDL) and oxidised high density lipoprotein (ox-HDL) on macrophages was studied and compared with that of low density lipoprotein (LDL). Copper-mediated oxidation of HDL and LDL was conducted in vitro and assessed by the analysis of conjugated dienes (CD). The kinetics of CD production during lipoprotein oxidation showed that HDL, relative to LDL, exhibited a shorter lag phase (47.

An enzyme-linked immunosorbent assay method to measure human apolipoprotein E levels using commercially available reagents: effect of apolipoprotein E polymorphism on serum apolipoprotein E concentration.

A sensitive and specific enzyme-linked immunosorbent assay (ELISA) for human apolipoprotein E (apo E) quantification using commercially available reagents is described. The assay is a noncompetitive, sandwich ELISA in which the wells were coated with a monoclonal EO1 antibody anti-human apo E and detected with a polyclonal antibody-peroxidase conjugate anti-apo E. The mean apo E concentration in 168 middle-aged subjects randomly selected from general population was 51.

[Effectiveness of hypercholesterolemia detection in high risk individuals compared to opportunistic detection].

Background: The aims of this study were to estimate the number of people who should receive some intervention (pharmacologic and/or dietetic) to reduce cholesterol concentrations and to evaluate selective case finding in comparison to opportunistic detection.

Methods: Six hundred twenty-five individuals participating in a study of cardiovascular risk factors were included in the study. Those with total cholesterol concentrations (TC) greater than 6.

A rapid procedure for eliminating chromatofocusing buffer and concentrating minor active subforms of mitochondrial malate dehydrogenase.

Mitochondrial malate dehydrogenase from several sources contains different molecular forms whose origin is still under discussion. Separation of these subforms has been achieved by chromatofocusing. A simple and rapid method, based on 5' AMP Sepharose chromatography, has been developed to concentrate mitochondrial malate dehydrogenase subforms and simultaneously remove chromatofocusing buffer.