A CYCLIC PEPTIDE TARGETS GLIOBLASTOMA BY BINDING TO ABERRANTLY EXPOSED SNAP25.

Disease-specific changes in tumors and other diseased tissues are an important target of research because they provide clues on the pathophysiology of the disease as well as uncovering potentially useful markers for diagnosis and treatment. Here, we report a new cyclic peptide, CESPLLSEC (CES), that specifically accumulated (homed) in intracranial U87MG and the WT-GBM model of glioblastoma from intravenous (IV) injection, associating with the vasculature. Affinity chromatography of U87MG tumor extracts on insolubilized CES peptide identified Synaptosomal Associated Protein 25 (SNAP25) as a candidate target molecule (receptor) for CES.

Boosted Photocatalytic Activities of AgCrO through Eu-Doping Process.

AgCrO is a representative member of a family of Ag-containing semiconductors with highly efficient visible-light-driven responsive photocatalysts. The doping process with Eu is known to effectively tune their properties, thus opening opportunities for investigations and application. Here, we report the enhancement of the photocatalytic activity and stability of AgCrO by introducing Eucations.

Functional connectivity of the amygdala subnuclei in various mood states of bipolar disorder.

Amygdala functional dysconnectivity lies at the heart of the pathophysiology of bipolar disorder (BD). Recent preclinical studies suggest that the amygdala is a heterogeneous group of nuclei, whose specific connectivity could drive positive or negative emotional valence. We investigated functional connectivity (FC) changes within these circuits emerging from each amygdala's subdivision in 127 patients with BD in different mood states and 131 healthy controls (HC), who underwent resting-state functional MRI.

Selectivity control towards CO versus H for photo-driven CO reduction with a novel Co(II) catalyst.

Developing efficient catalysts for reducing carbon dioxide, a highly stable combustion waste product, is a relevant task to lower the atmospheric concentration of this greenhouse gas by upcycling. Selectivity towards CO-reduction products is highly desirable, although it can be challenging to achieve since the metal-hydrides formation is sometimes favored and leads to H evolution. In this work, we designed a cobalt-based catalyst, and we present herein its physicochemical properties.

Evaluation of Cytocompatibility of PEEK-Based Composites as a Function of Manufacturing Processes.

The biocompatible polymer polyetheretherketone (PEEK) is a suitable candidate to be part of potential all-polymer total joint replacements, provided its use is associated with better osseointegration, mechanical performance, and wear resistance. Seeking to meet the aforementioned requirements, respectively, we have manufactured a PEEK composite with different fillers: carbon fibers (CF), hydroxyapatite particles (HA) and graphene platelets (GNP). The mechanical outcomes of the composites with combinations of 0, 1.

Biomechanical Behavior of Dynamic vs. Static Distal Locking Intramedullary Nails in Subtrochanteric Femur Fractures.

Objective: Hip fractures are one of the most frequent fractures presenting to the emergency department and orthopedic trauma teams. The aim of this study was to determine the best indication and therapeutic technique for subtrochanteric fractures and unifying criteria when choosing the most suitable type of nail.

Materials And Methods: To analyze the influence of the material and the type of distal locking of intramedullary nails (static or dynamic), a femur model with a fracture in the subtrochanteric region stabilized with a long Gamma intramedullary nail was applied using finite element method (FEM) simulation.

Three-Dimensional Computational Model Simulating the Initial Callus Growth during Fracture Healing in Long Bones: Application to Different Fracture Types.

Bone fractures are among the most common and potentially serious injuries to the skeleton, femoral shaft fractures being especially severe. Thanks to recent advances in the area of in silico analysis, several approximations of the bone healing process have been achieved. In this context, the objective of this work was to simulate the initial phase of callus formation in long bones, without a pre-meshed domain in the 3D space.

A Chemical-Pressure-Induced Phase Transition Controlled by Lone Electron Pair Activity.

The chemical pressure approach offers a new paradigm for property control in functional materials. In this work, we disclose a correlation between the β → α pressure-induced phase transition in SnMoO and the substitution process of Mo by W in SnMoWO solid solutions ( = 0-1). Special attention is paid to discriminating the role of the lone pair Sn cation from the structural distortive effect along the Mo/W substitution process, which is crucial to disentangle the driven force of the transition phase.

Analysis of Biophysical Variables in an Onion Crop ( L.) with Nitrogen Fertilization by Sentinel-2 Observations.

The production of onions bulbs ( L.) requires a high amount of nitrogen. According to the demand of sustainable agriculture, the information-development and communication technologies allow for improving the efficiency of nitrogen fertilization.

Predator control of marine communities increases with temperature across 115 degrees of latitude.

Early naturalists suggested that predation intensity increases toward the tropics, affecting fundamental ecological and evolutionary processes by latitude, but empirical support is still limited. Several studies have measured consumption rates across latitude at large scales, with variable results. Moreover, how predation affects prey community composition at such geographic scales remains unknown.

A Practical Approach for Uncertainty Management in Rubber Manufacturing Processes Using Physics-Informed Real-Time Models.

Industrial manufacturing management can benefit from the use of modeling. For a correct representation of the manufacturing process and the subsequent management, the models must incorporate the effect of the uncertainty propagation throughout the stages considered. In this paper, the proposed methodology for uncertainty management uses a nonintrusive method that is based on building a deterministic physics-informed real-time model for the a posteriori computation of output uncertainties.

Density-functional study of pressure-induced phase transitions and electronic properties of ZnVO.

We report a study of the high-pressure behavior of the structural and electronic properties of ZnVO by means of first-principle calculations using the CRYSTAL code. Three different approaches have been used, finding that the Becke-Lee-Yang-Parr functional is the one that best describes ZnVO. The reported calculations contribute to the understanding of previous published experiments.

Rubber Material-Model Characterization for Coupled Thermo-Mechanical Vulcanization Foaming Processes.

A novel experimental methodology is developed for the characterization of the vulcanization and foaming processes of an ethylene propylene diene (EPDM) cellular rubber and for establishing the relationship of its physical and mechanical property evolution with vulcanization and foaming process temperature. To establish this relationship, the vulcanization and foaming reaction kinetics and their coupling have been determined, as well as important parameters in the behaviour of the material, such as conductivity, specific heat capacity and coefficients of expansion and foaming. This aforementioned strategy allows the setting of a material model that can be implemented into finite-element (FE) codes to reproduce the material changes during the vulcanization and foaming processes.

A new approach for initial callus growth during fracture healing in long bones.

The incidence of bone fracture has become a major clinical problem on a worldwide scale. In the past two decades there has been an increase in the use of computational tools to analyse the bone fracture problem. In several works, various study cases have been analysed to compare human and animal bone fracture healing.

Are the unreamed nails indicated in diaphyseal fractures of the lower extremity? A biomechanical study.

Introduction: Intramedullary nailing is generally accepted as the first choice for the treatment of diaphyseal fractures of femur and tibia, with a gradual incease in the use of unreamed nails. Different studies during last years show controversial outcomes. Some authors strongly favor unreamed nailing, but most of the authors conclude that reamed nailing have proved to be more successful.

Monocyte/Macrophage Lineage Cells From Fetal Erythromyeloid Progenitors Orchestrate Bone Remodeling and Repair.

A third of the population sustains a bone fracture, and the pace of fracture healing slows with age. The slower pace of repair is responsible for the increased morbidity in older individuals who sustain a fracture. Bone healing progresses through overlapping phases, initiated by cells of the monocyte/macrophage lineage.

Identifying and explaining vibrational modes of sanbornite (low-BaSiO) and BaSiO: A joint experimental and theoretical study.

We report here the analysis of vibrational properties of the sanbornite (low-BaSiO) and BaSiO using theoretical and experimental approaches, as well as results of high temperature experiments up to 1100-1150 °C. The crystal parameters derived from Rietveld refinement and calculations show excellent agreement, within 4%, while the absolute mean difference between the theoretical and experimental results for the IR and Raman vibrational frequencies was <6 cm. The temperature-dependent Raman study renders that both sanbornite and BaSiO display specific Ba and Si sites and their BaO and SiO bonds.

Hsp90-interacting Co-chaperones and their Family Proteins in Tau Regulation: Introducing a Novel Role for Cdc37L1.

Tau is a microtubule-associated protein that serves as a promoter of microtubule assembly and stability in neuron cells. In a collective group of neurodegenerative diseases called tauopathies, tau processing is altered as a result of gene mutations and post-translational modifications. In particular, in Alzheimer's disease (AD) or AD-like conditions, tau becomes hyperphosphorylated and forms toxic aggregates inside the cell.

Structure, electronic properties, morphology evolution, and photocatalytic activity in PbMoO and PbCaSrMoO ( = 0.1, 0.2, 0.3, 0.4 and 0.5) solid solutions.

In this work PbMoO4 and Pb1-2xCaxSrxMoO4 (x = 0.1, 0.2, 0.

New Photosensitizers Based on Heteroleptic Cu Complexes and CO Photocatalytic Reduction with [Ni (cyclam)]Cl.

Earth-abundant metal complexes have been attracting increasing attention in the field of photo(redox)catalysis. In this work, the synthesis and full characterisation of four new heteroleptic Cu complexes are reported, which can work as photosensitizers. The complexes bear a bulky diphosphine (DPEPhos=bis[(2-diphenylphosphino)phenyl] ether) and a diimine chelating ligand based on 1-benzyl-4-(quinol-2'yl)-1,2,3-triazole.

Usefulness of a Point-of-Care Analyzer to Measure Cardiac Troponin I and D-Dimer Concentrations in Critically Ill Horses With Gastrointestinal Diseases.

Point-of-care (POC) systems for the joint measurement of Troponin and D-dimers have not been studied in horses. The aim of this study was to perform the validation of a POC system (AQT90 FLEX) for the measurement of cardiac troponin I (cTnI) and D-dimers in the serum of horses with gastrointestinal diseases. The main objective was to evaluate whether or not this system can distinguish healthy animals from diseased animals.

A New Multiparameter Model for Multiaxial Fatigue Life Prediction of Rubber Materials.

Most of the mechanical components manufactured in rubber materials experience fluctuating loads, which cause material fatigue, significantly reducing their life. Different models have been used to approach this problem. However, most of them just provide life prediction only valid for each of the specific studied material and type of specimen used for the experimental testing.