Osteoid osteoma of the hook of the hamate presenting as ulnar-sided wrist pain: A case report.

Osteoid osteomas are benign, typically intracortical lesions most often affecting the diaphyses of long bones. We describe a case involving a 26-year-old male laborer who presented with the insidious onset of ulnar-sided wrist pain. He was diagnosed with and successfully treated with surgical excision for an osteoid osteoma involving the hook of the hamate.

Colorectal microcarcinoids in association with long-term exposure to urinary content: a case report and review of the literature.

Long-term exposure of colonic mucosa to urinary content and its association with increased risk of infection, mechanical and biochemical irritation, and malignancy have been described in the literature. Existing case reports and studies depict the low but distinct risk of malignancy in gastrointestinal segments which come in contact with urinary content as a result of surgical correction of urinary tract abnormalities. However, these reports are largely limited to colonic adenocarcinoma and urothelial cell carcinoma.

BRAF mutation testing in solid tumors: a methodological comparison.

Solid tumor genotyping has become standard of care for the characterization of proto-oncogene mutational status, which has traditionally been accomplished with Sanger sequencing. However, companion diagnostic assays and comparable laboratory-developed tests are becoming increasingly popular, such as the cobas 4800 BRAF V600 Mutation Test and the INFINITI KRAS-BRAF assay, respectively. This study evaluates and validates the analytical performance of the INFINITI KRAS-BRAF assay and compares concordance of BRAF status with two reference assays, the cobas test and Sanger sequencing.