Publications by authors named "Grace Roper"
Article Synopsis
- - Ten-eleven translocation enzymes (TETs) are important enzymes involved in modifying DNA by converting 5-methylcytosine to various other forms, which plays a role in gene regulation and epigenetics.
- - The research investigates how certain inhibitors of 2-oxoglutarate (2OG) oxygenases, including some already used in clinical settings, affect the activity of human TET1-3 enzymes, showing that most inhibitors have similar effects across these TETs.
- - Notably, the oncometabolite 2-hydroxyglutarate exhibited varying levels of inhibition on TET1, TET2, and TET3, which may have implications for understanding cancer development and
Post-translational modifications (PTMs) greatly expand the structures and functions of proteins in nature. Although synthetic protein functionalization strategies allow mimicry of PTMs, as well as formation of unnatural protein variants with diverse potential functions, including drug carrying, tracking, imaging and partner crosslinking, the range of functional groups that can be introduced remains limited. Here we describe the visible-light-driven installation of side chains at dehydroalanine residues in proteins through the formation of carbon-centred radicals that allow C-C bond formation in water.
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