A 56-Day Oral Toxicity Study of the Aqueous Extract of (L.) Mez in Rats.

is a tropical tree that is extensively utilized in African traditional medicine to treat helminthiases, tuberculosis, and heart-water. As with many other medicinal plants, there is insufficient information regarding the safety of therapeutic extracts. An aqueous extract of stem bark was administered to Sprague Dawley rats at doses of 100 mg/kg, 300 mg/kg, and 1000 mg/kg for 56 days to characterize its potential toxicity after prolonged dosing.

Sub-acute toxicity of the chloroformic extract of Rapanea melanophloeos (L.) Mez in rats.

Ethnopharmacological Relevance: Cape beech (Rapanea melanophloeos) is an important medicinal plant that is widely used in most of Africa. Currently, little toxicological information is available on its safety following prolonged use.

Aim Of The Study: In this study, we sought to evaluate the oral sub-acute toxicity of Rapanea melanophloeos stem bark chloroformic extract using Sprague Dawley rats.