Publications by authors named "Grace Li-Na Su"
Complete encapsulation of nucleic acids by lipid-based nanoparticles (LNPs) is often thought to be one of the main prerequisites for successful nucleic acid delivery, as the lipid environment protects mRNA from degradation by external nucleases and assists in initiating delivery processes. However, delivery of mRNA via a preformed vesicle approach (PFV-LNPs) defies this precondition. Unlike traditional LNPs, PFV-LNPs are formed via a solvent-free mixing process, leading to a superficial mRNA localization.
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- Ocular delivery of lipid nanoparticles (LNPs) containing mRNA facilitates gene delivery and editing for potential treatments related to blindness.
- Different LNP variants, such as LNPa, LNPx, and LNPz, show varying efficacy in transfecting retinal cells, with LNPx demonstrating significant distribution across photoreceptors and the retinal pigmented epithelium (RPE).
- LNPs modified with PEG variants can influence how effectively mRNA is taken up by specific retinal cells, paving the way for future gene editing to correct genetic mutations associated with vision loss.