Psilocybin Conspectus: Status, Production Methods, and Considerations.

Psilocybin is a psychoactive alkaloid that is produced naturally by approximately 200 species of mushrooms. The potential medical use of this molecule for the treatment of mental illness is gaining renewed momentum. As demand grows and clinical trials progress, appropriate methods for producing a quality pharmaceutical product are needed.

The relationship between Type D personality and insomnia.

Objectives: Type D personality is characterized by the combination of social inhibition and negative affectivity. This study examined the relationship between Type D personality and insomnia symptoms amongst a sample of the general-population.

Methods: Adults from the general-population (n = 392) completed online measures of Type D personality (DS14) and insomnia severity.

Mechanical Strength of the Proximal Tibia Following Total Knee Arthroplasty: A Cadaveric Study of Resection Depth and Bone Density.

Background: Tibial component failure has been a problem in total knee arthroplasty, it is still undetermined how tibial resection depth affects the strength to support a tibial component. This study examined the relationship between the resection depth and the bone density and the mechanical strength to support the tibial component.

Materials And Methods: Eight matched pairs of fresh, frozen cadaver lower legs were imaged with computed tomography to assess the bone density.