Publications by authors named "Grace E Whipple"
Acute kidney injury results in long-term alterations of kidney lymphatics in mice.
Am J Physiol Renal Physiol
November 2024
Article Synopsis
- This study investigates the long-term effects of acute kidney injury (AKI) caused by bilateral ischemia-reperfusion injury (BIRI) on kidney lymphatic dynamics in mice over a period of up to 9 months.
- While kidney function initially recovered, the researchers found ongoing tissue damage and inflammation through histological analysis, indicating lasting effects of the injury.
- The study highlights distinct phases of lymphatic responses with unique transcriptional signatures, immune cell changes, and the formation of new lymphatic structures, suggesting a critical link between AKI and the development of chronic kidney disease.