Aging-Associated Augmentation of Gut Microbiome Virulence Capability Drives Sepsis Severity.

Prior research has focused on host factors as mediators of exaggerated sepsis-associated morbidity and mortality in older adults. This focus on the host, however, has failed to identify therapies that improve sepsis outcomes in the elderly. We hypothesized that the increased susceptibility of the aging population to sepsis is not only a function of the host but also reflects longevity-associated changes in the virulence of gut pathobionts.

Aging-associated augmentation of gut microbiome virulence capability drives sepsis severity.

Unlabelled: Prior research has focused on host factors as mediators of exaggerated sepsis-associated morbidity and mortality in older adults. This focus on the host, however, has failed to identify therapies that improve sepsis outcomes in the elderly. We hypothesized that the increased susceptibility of the aging population to sepsis is not only a function of the host, but also reflects longevity-associated changes in the virulence of gut pathobionts.

Cardiac Toxicity and Anthracyclines: Mechanism, Interventions, and the Trouble With Troponin.

As cancer survivorship increases, clinicians need to become educated regarding the long-term effect of cancer treatments. Cancer therapeutics-related cardiac dysfunction (CTRCD) is one such sequela that contributes to significant morbidity and mortality. Unfortunately, screening and management practices regarding CTRCD are inconsistent within guidelines and practice.

Walking the red road: the role of First Nations grandparents in promoting cultural well-being.

The purpose of this grounded theory study was to provide a framework for understanding the contemporary experience of First Nations grandparents. Fifteen respondents (N = 15) were selected from two demographically different Canadian cities. Seven of the grandparents lived with their child and a grandchild or grandchildren at the time of the interview; an additional four had lived with their grandchildren at some point prior to this investigation.