Publications by authors named "Grace Crossland"
Considerations and Approaches for Cancer Immunotherapy in the Aging Host.
Cancer Immunol Res
November 2023
Advances in cancer immunotherapy are improving treatment successes in many distinct cancer types. Nonetheless, most tumors fail to respond. Age is the biggest risk for most cancers, and the median population age is rising worldwide.
View Article and Find Full Text PDFLymphocytes are key for immune surveillance of tumors, but our understanding of the spatial organization and physical interactions that facilitate lymphocyte anti-cancer functions is limited. We used multiplexed imaging, quantitative spatial analysis, and machine learning to create high-definition maps of lung tumors from a Kras/Trp53-mutant mouse model and human resections. Networks of interacting lymphocytes ("lymphonets") emerged as a distinctive feature of the anti-cancer immune response.
View Article and Find Full Text PDFArticle Synopsis
- CD8 T cell responses to different tumor neoantigens happen at the same time, but how they influence each other and overall tumor control is not well understood.
- In a mouse model of lung adenocarcinoma, it was discovered that the most stable binding of an antigen to MHC drives the dominant CD8 T cell expansion, while subdominant T cells show a TCF1 progenitor phenotype linked to immune checkpoint blockade (ICB) therapy responses.
- However, a dysfunctional subset of subdominant TCF1 cells, identified by markers like CCR6 and Tc17 differentiation, limits their benefit from ICB, but using vaccination helps eliminate these cells and enhances the subdominant T cell response against tumors.