Publications by authors named "Grace C Westerkamp"
Interneuron loss is a prominent feature of temporal lobe epilepsy in both animals and humans and is hypothesized to be critical for epileptogenesis. As loss occurs concurrently with numerous other potentially proepileptogenic changes, however, the impact of interneuron loss in isolation remains unclear. For the present study, we developed an intersectional genetic approach to induce bilateral diphtheria toxin-mediated deletion of Vgat-expressing interneurons from dorsal and ventral hippocampus.
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- Acquired epilepsies begin after a brain injury, leading to the gradual development of seizures, but the processes behind this progression (epileptogenesis) are not fully understood; microRNAs like miR-324-5p have been linked to regulating these processes.
- In a study with mice, researchers tested the effects of inhibiting miR-324-5p during the epileptogenesis phase by using a specific model (IHpKa) and monitoring through EEG for 28 days.
- The findings showed that inhibiting miR-324-5p did not prevent the onset or severity of seizures but did affect certain EEG activity patterns, suggesting that timing of treatment is crucial and that miR-324-5