Publications by authors named "Grace C Chamberlin"
Article Synopsis
- Vaccination status (vaccinated vs. unvaccinated) influences protective immunity against SARS-CoV-2 variants, particularly Delta and Omicron.
- Higher viral loads during infection correlate with lower antibody responses, highlighting the relationship between viral exposure and immune response.
- Convalescent antibody responses vary by variant: vaccinated individuals generally have stronger neutralization against variants, while unvaccinated responses are weaker, with specific differences noted between Delta and Omicron variants.
We enrolled 7 individuals with recurrent symptoms or antigen test conversion following nirmatrelvir-ritonavir treatment. High viral loads (median 6.1 log10 copies/mL) were detected after rebound for a median of 17 days after initial diagnosis.
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- There is evidence that the risk of getting infected with SARS-CoV-2 varies based on the variant, affecting how well vaccines protect against the virus.
- Researchers analyzed vaccinated and unvaccinated individuals with Delta or Omicron infections, measuring viral loads and antibodies.
- Results showed vaccinated individuals had higher neutralizing antibody levels than unvaccinated ones, and responses were variant-specific, with the Delta variant showing weaker responses against BA.2 and Omicron generating broader protection against multiple variants.
Clinical features of SARS-CoV-2 Omicron variant infection, including incubation period and transmission rates, distinguish this variant from preceding variants. However, whether the duration of shedding of viable virus differs between omicron and previous variants is not well understood. To characterize how variant and vaccination status impact shedding of viable virus, we serially sampled symptomatic outpatients newly diagnosed with COVID-19.
View Article and Find Full Text PDFIsolation guidelines for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are largely derived from data collected prior to the emergence of the delta variant. We followed a cohort of ambulatory patients with postvaccination breakthrough SARS-CoV-2 infections with longitudinal collection of nasal swabs for SARS-CoV-2 viral load quantification, whole-genome sequencing, and viral culture. All delta variant infections in our cohort were symptomatic, compared with 64% of non-delta variant infections.
View Article and Find Full Text PDFDuring the COVID-19 pandemic, rapid, real-world evidence is essential for the development of knowledge and subsequent public health response. In dermatology, provider-facing and patient-facing registries focused on COVID-19 have been important sources of research and new information aimed at guiding optimal patient care. The 7 dermatology registries included in this update now include more than 8000 case reports sourced from physicians and patients from countries all over the world.
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