Publications by authors named "Grace C Birch"
Article Synopsis
- Conventional donor lymphocyte infusion has low effectiveness for treating relapses after hematopoietic cell transplantation, prompting a trial of cytokine-induced memory-like (CIML) NK cell therapy in patients with myeloid malignancies.
- In a phase I trial, 6 patients received donor-derived NK cells, resulting in rapid and sustained expansion of these cells post-infusion without serious adverse effects, although mild fever and pancytopenia were noted.
- The successful expansion and long-term presence of CIML NK cells indicate their potential for treating relapses after transplantation, and further research is needed to understand their interactions with other immune cells and the tumor environment.
