Publications by authors named "Grace Alchemy"
Article Synopsis
- Ferroptosis is a form of cell death linked to iron and lipid damage, showing potential for cancer treatment, particularly involving lipid peroxidation of specific fatty acids.
- GPX4 normally prevents ferroptosis by converting harmful lipid hydroperoxides into less harmful forms, making it a potential drug target whose sensitivity is not well understood.
- Research indicates that cancer cells cultured in 3D conditions produce fewer polyunsaturated fatty acids and more monounsaturated fatty acids, which can help them resist ferroptosis and reduce the effectiveness of GPX4 inhibitors.
Cancer cells need a steady supply of nutrients to evade cell death and proliferate. Depriving cancer cells of the amino acid cystine can trigger the non-apoptotic cell death process of ferroptosis. Here, we report that cancer cells can evade cystine deprivation-induced ferroptosis by uptake and catabolism of the cysteine-rich extracellular protein albumin.
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