Publications by authors named "Grace A H Nguyen"
High-resolution scans of immunohistochemical (IHC) stains of Alzheimer's disease (AD) brain slices and radioligand autoradiography both provide information about the distribution of Aβ plaques and Tau, the two common proteinopathies in AD. Accurate assessment of the amount and regional location of Aβ plaques and Tau is essential to understand the progression of AD pathology. Our goal was to develop a quantitative method for the analysis of IHC-autoradiography images.
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- Several fluorine-18-labeled PET radiotracers for imaging β-amyloid plaques in Alzheimer's disease are in clinical use, but no radioiodinated agents have successfully advanced for SPECT or PET until now.
- The study focuses on a new iodine-124-labeled compound, [124I]IBETA, which shows high binding affinity and specificity for Aβ plaques in a 5 × FAD mouse model and postmortem human AD brains.
- Results indicate that [124I]IBETA has a high radiochemical yield, strong correlation with anti-Aβ staining, and preliminary PET/CT studies suggest effective localization in brain regions rich in Aβ plaques.