Publications by authors named "Grac Raposo"
Proc Natl Acad Sci U S A
December 2008
Article Synopsis
- Melanosomes are specialized organelles responsible for synthesizing and storing melanins, with early-stage melanosomes featuring fibrils that serve as a foundation for melanin deposition.
- The protein Pmel17 plays a key role in forming these fibrils and is found to initiate fibril formation independently of other specific proteins, though the exact processes behind this are not fully understood.
- Advanced imaging techniques reveal that fibril formation begins in multivesicular endosomes, suggesting a connection between melanin synthesis and membrane structures, which may also relate to amyloid formation in disease contexts.
