Atopy patch testing with aeroallergens in a large clinical population of dermatitis patients in Germany and Switzerland, 2000-2015: a retrospective multicentre study.

Background: The diagnostic significance of the atopy patch test for the management of dermatitis possibly triggered by aeroallergens is still controversial. However, sufficiently large studies with routinely tested standardized aeroallergen patch test preparations in dermatitis patients are lacking.

Objective: To evaluate the reaction frequency and the reaction profiles of 10 until mid-2015 commercially available, standardized aeroallergen patch test preparations of the 'Stallerpatch' test series (Stallergenes, Antony Cedex, France) in a large multicentre patient cohort.

Goblet cell carcinoid of the appendix: Case report of a high grade tumor in a 20-year-old.

Introduction: Goblet cell carcinoid (GCC) is an extraordinarily rare appendiceal tumor that is usually an incidental diagnosis on post-operative histology. It typically presents in the fifth or sixth decade of life. Our patient is the only reported case study of GCC in a pediatric-young adult.

Food-induced anaphylaxis and cofactors - data from the anaphylaxis registry.

Food allergens are frequent causes of anaphylaxis. In particular in children and adolescents they are the most frequent elicitors of severe allergic reactions, and in adults food allergens rank third behind insect venom and drugs. Since July 2006 severe allergic reactions from Germany, Austria, and Switzerland are collected in the anaphylaxis registry.

Letter Position Coding with Fred Astaire: Inversion of Letter Position Substitution Effects in Reverse Spelled Words.

The effects of letter substitutions have been linked to their position within a word (letter position effects). The current study expanded upon previous research by examining letter-position effects for letter substitutions using forward- and reverse-spelled word primes. Often substituting a letter on one side of a word will have a stronger impact on performance than substituting a letter on the other side of a word.

[Prurigo pigmentosa after fat-reduced diet, treated with doxycycline].

Prurigo pigmentosa is a rare inflammatory skin disease of unknown origin, mostly described in the ethnic Japanese population. Etiology and pathogenesis are not completely known. Tetracyclines or dapsone are the therapy of choice.

Word Frequency Effects for LEET Lettering in Word Recognition.

Letter substitution has been shown to have a cost to word recognition performance, such as increased reaction time. The use of orthographically similar numbers or symbols as a substitute for letters is known as LEET. Perea, Duñabeitia, and Carreiras (2008) showed that word recognition was not affected when LEET substitutions were used as primes.

Cutaneous manifestations in patients with mastocytosis: Consensus report of the European Competence Network on Mastocytosis; the American Academy of Allergy, Asthma & Immunology; and the European Academy of Allergology and Clinical Immunology.

Cutaneous lesions in patients with mastocytosis are highly heterogeneous and encompass localized and disseminated forms. Although a classification and criteria for cutaneous mastocytosis (CM) have been proposed, there remains a need to better define subforms of cutaneous manifestations in patients with mastocytosis. To address this unmet need, an international task force involving experts from different organizations (including the European Competence Network on Mastocytosis; the American Academy of Allergy, Asthma & Immunology; and the European Academy of Allergology and Clinical Immunology) met several times between 2010 and 2014 to discuss the classification and criteria for diagnosis of cutaneous manifestations in patients with mastocytosis.

Interinstitutional whole slide imaging teleconsultation service development: assessment using internal training and clinical consultation cases.

Context: Assessment of accuracy and feasibility of whole slide imaging (WSI) for interinstitutional consultation in surgical pathology.

Objectives: To train technical and pathologist staff in WSI technology, establish and evaluate a WSI workflow using training cases and second-opinion consultations, and assess diagnostic accuracy.

Design: First, WSI training and evaluation using selected subspecialty service cases were performed and compared with the clinical glass slide (GS) diagnosis.

Effects of targets embedded within words in a visual search task.

Visual search performance can be negatively affected when both targets and distracters share a dimension relevant to the task. This study examined if visual search performance would be influenced by distracters that affect a dimension irrelevant from the task. In Experiment 1 within the letter string of a letter search task, target letters were embedded within a word.

Age-related sparing of parafoveal lexical processing.

Unlabelled: BACKGROUND/STUDY CONTEXT: This study examined the role of increased adult age in the processing of lexical information presented in foveal and parafoveal areas of the retina (right and left visual fields). Previous research has shown that older adults are able to compensate for age-related changes though a highly practiced skill (Salthouse, 1984 , Journal of Experimental Psychology: General, 113, 345-371). The authors examined if older adults would show a lexical-only parafoveal benefit.

Cross-task compatibility and age-related dual-task performance.

Unlabelled: BACKGROUND/STUDY CONTEXT: This study examined the effects of stimulus-stimulus and response-response cross-task compatibility and aging on dual-task performance. Hypothesis 1 predicted that the response code compatibility effect in both experiments would benefit older adults comparably to younger adults. Hypothesis 2 predicted that stimulus-stimulus compatibility would be additive to the effects of cross-task compatibility.

Efficacy and safety of omalizumab in patients with chronic urticaria who exhibit IgE against thyroperoxidase.

Background: A subgroup of patients with chronic spontaneous urticaria (CU) exhibits IgE antibodies directed against autoantigens, such as thyroperoxidase (TPO). We conducted this study to investigate whether such patients with CU with IgE against TPO benefit from treatment with omalizumab, a humanized anti-IgE mAb licensed for the treatment of severe persistent allergic (IgE-mediated) asthma.

Objectives: We sought to assess the efficacy of omalizumab treatment in patients with CU with IgE autoantibodies against TPO.

Influence of encoding difficulty, word frequency, and phonological regularity on age differences in word naming.

It is presently unclear as to why older adults take longer than younger adults to recognize visually presented words. To examine this issue in more detail, the authors conducted two word-naming studies (Experiment 1: 20 older adults and 20 younger adults; Experiment 2: 60 older adults and 60 younger adults) to determine the relative effects of orthographic encoding (case type), lexical access (word frequency), and phonological regularity (regular vs. irregular phonology).

Icatibant, a new bradykinin-receptor antagonist, in hereditary angioedema.

Background: Hereditary angioedema is characterized by recurrent attacks of angioedema of the skin, larynx, and gastrointestinal tract. Bradykinin is the key mediator of symptoms. Icatibant is a selective bradykinin B2 receptor antagonist.

Increased sensitivity of patch testing by standardized tape stripping beforehand: a multicentre diagnostic accuracy study.

Background: As a modification of patch testing, the strip patch test was established to obtain more sensitive and reliable test results. Comparative data on diagnostic accuracy for both tests are missing.

Objectives: To compare the diagnostic accuracy of strip patch tests and patch tests in detecting sensitizations in patients with suspected allergic contact dermatitis by using patient history as the reference standard.

Urticaria: its history-based diagnosis and etiologically oriented treatment.

Introduction: The term "urticaria" refers to any of a group of distinct skin conditions that are characterized by itchy, wheal-and-flare skin reactions (hives). In spontaneous urticaria, the most common type, the hives seem to arise without provocation.

Methods: Selective review of the literature, including current guidelines.

[Sociomedical implications of the inability to commute in patients with cold urticaria].

One of the important functions of the dermatologist working within a social medicine framework is the determination of social security disability benefits. The primary decision deals with the question which type of work the applicant can be asked to do and to what extent. Depending on the results of the medical assessment, social security disability benefits may be approved given that other insurance criteria specific to the applicant have been met.

[Two faces of Janus. Coexistence of systemic lupus erythematosus and psoriasis in the same patient].

While both lupus erythematosus and psoriasis are inflammatory dermatoses characterized by scaly erythematous plaques, they are rarely confused in clinical practice. We report a woman who alternately presented with lupus erythematosus and psoriasis over 14 years but the former condition was not recognized and adequately treated. After the complete diagnosis had been established, a combination of thalidomide and acitretin resulted in a prolonged remission of both disorders.

The early bird does not get the worm: time-of-day effects on college students' basic cognitive processing.

We conducted a neuropsychological and cognitive assessment study to determine whether time of day affects cognitive performance. We measured executive control (fluency), processing speed, semantic memory, and episodic memory performance. We followed 56 students across 3 different times of day, testing performance on vocabulary, fluency, processing speed, and episodic memory.

Visual word recognition without central attention: evidence for greater automaticity with greater reading ability.

The present study examined individual differences in the automaticity of visual word recognition. Specifically, we examined whether people can recognize words while central attention is devoted to another task and how this ability depends on reading skill. A lexical-decision Task 2 was combined with either an auditory or visual Task 1.

Treatment of severe pemphigus with protein A immunoadsorption, rituximab and intravenous immunoglobulins.

Background: Pemphigus is a life-threatening autoimmune blistering disease usually treated with high-dose corticosteroids and other immunosuppressants. However, this regimen may prove inadequate in severe cases and cause dangerous side-effects. While protein A immunoadsorption (PAIA) induces a rapid remission in severe pemphigus, the disease usually recurs once the treatment is stopped.