Publications by authors named "Gr Wu"

Background: As the global population ages, the prevalence of neurodegenerative conditions, such as Alzheimer's disease (AD), Parkinson's disease (PD), dementia with Lewy bodies, and frontotemporal dementia, continues to rise. Understanding the impact of aging on striatal glucose metabolism is pivotal in identifying potential biomarkers for the early detection of these disorders.

Methods: We investigated age-related changes in striatal glucose metabolism using both region of interest (ROI)-based and voxel-wise correlation analyses.

View Article and Find Full Text PDF

Purpose: The paper aims to investigate the factors influencing cancer-related fatigue (CRF) in lung cancer patients and construct a CRF risk prediction model, providing effective intervention strategies for clinical medical staff.

Methods: This paper employs convenience sampling to select 400 lung cancer patients who visited a tertiary hospital in Dazhou, Sichuan Province, from January 2021 to January 2022. A questionnaire survey was conducted using the Revised Piper Fatigue Scale (PFS-R), Pittsburgh Sleep Quality Index (PSQI), and Hospital Anxiety and Depression Scale (HADS) to collect data on patient demographics and sociological characteristics, disease-related information, physiological indicators, sleep quality, mental health, and other relevant factors.

View Article and Find Full Text PDF

Ruminative reflection has been linked to enhanced executive control in processing internally represented emotional information, suggesting it may serve as an adaptive strategy for emotion regulation. Investigating the neural substrates of reflection can deepen our understanding of its adaptive properties. This study used network-based statistic (NBS)-Predict methodology to identify resting state functional connectivity (FC)-based predictors of ruminative reflection in a healthy sample.

View Article and Find Full Text PDF
Article Synopsis
  • * Although there were significant differences in LC connectivity between the groups, baseline LC connectivity did not predict treatment outcomes with HF-rTMS; however, post-treatment improvements showed a correlation with changes in LC connectivity and cognitive regions.
  • * The research highlights the influence of state anxiety on HF-rTMS efficacy in treating MDD, suggesting that understanding LC connectivity and anxiety levels can help tailor personalized treatment strategies.
View Article and Find Full Text PDF

Background: This study investigates the effects of accelerated high-frequency repetitive transcranial magnetic stimulation (aHF-rTMS), applied to the left dorsolateral prefrontal cortex (DLPFC), on locus coeruleus (LC) functional connectivity in the treatment of refractory medication-resistant major depression (MRD).

Methods: We studied 12 antidepressant-free refractory MRD patients, focusing on how aHF-rTMS affects the LC, a central component of the brain's noradrenergic system and key to mood regulation and stress response.

Results: A stronger decrease in LC functional connectivity following aHF-rTMS treatment resulted in better clinical improvement.

View Article and Find Full Text PDF
Article Synopsis
  • Trait and state rumination contribute to negative emotions but are only weakly correlated, suggesting they influence emotional reactions to stress differently.
  • This study used functional near-infrared spectroscopy (fNIRS) and connectome-based predictive modeling (CPM) to identify distinct neural connectivity associated with each type of rumination.
  • Results showed that trait rumination involves broader functional connectivity networks, while state rumination has a more specific connectivity pattern, indicating shared neural mechanisms and potential targets for therapy to reduce rumination-related negativity.
View Article and Find Full Text PDF

Phasic cardiac vagal activity (CVA), reflecting ongoing, moment-to-moment psychophysiological adaptations to environmental changes, can serve as a predictor of individual difference in executive function, particularly executive performance. However, the relationship between phasic CVA and executive function demands requires further validation because of previous inconsistent findings. Moreover, it remains unclear what types of phasic changes of CVA may be adaptive in response to heightened executive demands.

View Article and Find Full Text PDF

Introduction: Pulmonary fibrosis (PF) is a fatal fibrotic lung disease without any options to halt disease progression. Feasible evidence suggests that aberrant metabolism of amino acids may play a role in the pathoetiology of PF. However, the exact impact of kynurenine (Kyn), a metabolite derived from tryptophan (Trp) on PF is yet to be addressed.

View Article and Find Full Text PDF

Sensitivity to criticism, which can be defined as a negative evaluation that a person receives from someone else, is considered a risk factor for the development of psychiatric disorders in adolescents. They may be more vulnerable to social evaluation than adults and exhibit more inadequate emotion regulation strategies such as rumination. The neural network involved in dealing with criticism in adolescents may serve as a biomarker for vulnerability to depression.

View Article and Find Full Text PDF
Article Synopsis
  • Protein identification at the single-molecule level is challenging, particularly for those with similar structures, but solid-state nanopores are being used as sensitive biosensors to assist with this.
  • The study focuses on two proteins, ferritin and apo-ferritin, which have the same exterior but different interior structures, demonstrating that nanopore size is crucial for effective discrimination between them.
  • By adjusting nanopore size, the researchers found that larger pores did not differentiate the proteins, whereas smaller pores allowed for clear discrimination through current fluctuations caused by the proteins' movements, suggesting this method could be applied to other similar proteins.
View Article and Find Full Text PDF

Previous neuroimaging studies have investigated brain morphology associated with internet addiction tendency (IAT) in healthy subjects. However, whether resting vagally-mediated heart rate variability (HRV) exerting influences on the association of IAT and brain morphology remains unclear. This study used voxel-based morphometry (VBM) and multiple regression analyses to assess the interaction effect of IAT and resting vagally-mediated HRV on regional grey matter volumes in 82 healthy subjects.

View Article and Find Full Text PDF

Early detection in the development of a Major Depressive Disorder (MDD) could guide earlier clinical interventions. Although MDD can begin at a younger age, most people have their first episode in young adulthood. The underlying pathophysiological mechanisms relating to such an increased risk are not clear.

View Article and Find Full Text PDF

Background: Major depressive disorder (MDD) is a severe psychiatric disorder affecting women more than men. Changes in anterior cingulate cortex cortical thickness (ACC CT) may be crucial to understanding sex influences in MDD onset and recurrency.

Methods: Taken from the large open-source REST-meta-MDD database, we contrasted 499 patients with MDD (381 first-episode MDD, 118 recurrent MDD) and 524 healthy control participants using linear mixed-effects models and normative modeling and investigated whether sex differences affected ACC CT and its subregions differently during the course of depressive illness.

View Article and Find Full Text PDF

Background: Acute alcohol-related behavioral disinhibition has been well studied. But whether individual differences in the personality trait sensation seeking affect alcohol-induced behavioral disinhibition remains uncertain.

Methods: The present study used functional near-infrared spectroscopy (fNIRS) technique and a response inhibition task (i.

View Article and Find Full Text PDF

Background: It has been widely accepted that major depressive disorder (MDD) impacts brain structures including the Corpus Callosum (CC). However, this assumption is based on scarce literature data involving small sample sizes. Furthermore, it is still unclear whether such CC volume changes may already be present at a first depressive episode.

View Article and Find Full Text PDF
Article Synopsis
  • Anxiety and fear are common but dysfunctional behaviors in dogs, similar to those in humans, yet little is known about the brain networks involved in canine anxiety disorders.
  • A study utilized diffusion tensor imaging (DTI) and graph theory to examine the brain structure of anxious dogs compared to healthy ones, revealing notable differences in their brain connectivity and efficiency.
  • Findings indicated that anxious dogs had decreased clustering and global efficiency in brain networks, particularly in regions like the occipital lobe and cerebellum, and these differences correlated with certain behavioral traits measured by a validated questionnaire.
View Article and Find Full Text PDF

Predicting clinical response to repetitive transcranial magnetic stimulation (rTMS) in medication-resistant depression (MRD) has gained great importance in recent years. Mainly, the right subgenual anterior cingulate cortex (sgACC) functional connectivity has been put forward as biomarker in relation to rTMS clinical outcome. Even though the left and right sgACC may have different neurobiological functions, little is known about the possible lateralized predictive role of the sgACC in rTMS clinical outcome.

View Article and Find Full Text PDF

White matter (WM) makes up half of the human brain. Compelling functional MRI evidence indicates that white matter exhibits neural activation and synchronization via a hemodynamic window. However, the neurometabolic underpinnings of white matter temporal synchronization and spatial topology remain unknown.

View Article and Find Full Text PDF

Background: As part of repetitive negative thinking (RNT), rumination is a maladaptive cognitive response style to stress or negative mood which can increase the risk of depression and may prohibit complete recovery. Cognitive behavioral therapy (CBT) and transcranial direct current stimulation (tDCS) both proved to be effective in decreasing rumination. However, the combined effects of tDCS and CBT interventions on rumination have not yet been explored.

View Article and Find Full Text PDF

Despite past extensive studies, the pathoetiologies underlying tumor metastasis remain poorly understood, which renders its treatment largely unsuccessful. The methyl-CpG-binding domain 2 (MBD2), a "reader" to interpret DNA methylome-encoded information, has been noted to be involved in the development of certain types of tumors, while its exact impact on tumor metastasis remains elusive. Herein we demonstrated that patients with LUAD metastasis were highly correlated with enhanced MBD2 expression.

View Article and Find Full Text PDF

Tetracyclines are one class of widely used antibiotics. Meanwhile, due to abuse and improper disposal, they are often detected in wastewater, which causes a series of environmental problems and poses a threat to human health and safety. As an efficient and environmentally friendly method, enzymatic catalysis has attracted much attention.

View Article and Find Full Text PDF

Aberrant activation of receptor tyrosine kinase (RTK) is usually a result of mutation and plays important roles in tumorigenesis. How RTK without mutation affects tumorigenesis remains incompletely understood. Here we show that in human melanomas pro-prion (pro-PrP) is an adaptor protein for an E3 ligase c-Cbl, enabling it to polyubiquitinate activated insulin-like growth factor-1 receptor (IGF-1R), leading to enhanced melanoma metastasis.

View Article and Find Full Text PDF

Objective: To address the role of methyl-CpG-binding domain 2 (MBD2) in the pathogenesis of asthma and its potential as a target for the asthmatic therapy.

Methods: Studies were conducted in asthmatic patients and macrophage-specific knockout mice to dissect the role of MBD2 in asthma pathogenesis. Additionally, RNAi-based therapy with siRNA-loaded liposomes was conducted in an ovalbumin (OVA)-induced allergic airway inflammation mouse model.

View Article and Find Full Text PDF

A PHP Error was encountered

Severity: Warning

Message: fopen(/var/lib/php/sessions/ci_sessiont21kk1hpljj2dhlj6i55bpv012o5eoro): Failed to open stream: No space left on device

Filename: drivers/Session_files_driver.php

Line Number: 177

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once

A PHP Error was encountered

Severity: Warning

Message: session_start(): Failed to read session data: user (path: /var/lib/php/sessions)

Filename: Session/Session.php

Line Number: 137

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once