SIGNIFICANCE OF ADC MEASUREMENTS AS RADIOLOGICAL MRI MARKER IN DETECTION OF METASTATIC LYMPH NODE INVOLVEMENT IN PATIENTS WITH PROSTATE CANCER.

Background: In spite of significant advances in diagnosis of prostate cancer (PCa), the detection and differential diagnosis of metastatic lymph node involvement remains an important clinical dilemma in a large number of cases. Contrast-enhanced abdominal computed tomography and magnetic resonance imaging (MRI), in part when using T1-weighed images (T1-WI and T2-WI), allow evaluating indirectly the presence of invasion in regional lymph nodes by assessing their diameter and morphology. Nonetheless, these techniques do not appear to be sufficiently sensitive for direct identification of lymph nodes with metastatic lesions.

Vitamin D supplementation to treat SARS-CoV-2 positive patients. Evidence from meta-analysis.

Background: Vitamin D is a likely candidate for treatment as its immune modulating characteristics have effects on coronavirus disease 2019 (COVID-19) patients. It was sought herein, to summarize the studies published to date regarding the vitamin D supplementation to treat severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) positive patients.

Methods: A systematic review and meta-analysis were performed following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement.

Predicting changes in glomerular filtration rate in patients with kidney cancer using a mathematical model.

Chronic renal failure is one of the most challenging complications after the completed surgical treatment for renal cell cancer. In 2016, a grading system of tumorous renal involvement was developed, referred to as NCIU nephrometry. However, the systematic parameter to reflect the functional status of the functional renal parenchyma is defined by tumor volume only, with no regard for spatial disposition of the segment(s) where the tumor is located.

Early Coaching to Increase Water Intake in CKD.

Introduction: In observational studies, increased water intake improves kidney function but not in adults with CKD stage 3 and more. CKD WIT trial has shown a nonsignificant gradual decline in kidney function after 1 year of coaching to increase water intake (CIWI) [1]. We propose that CIWI may benefit in CKD stage 1-2 (G1 and G2) and depends on functional renal functional reserve (RFR) [2, 3].

The role of macronutrients in the implementation of the corrective effect of low-mineralized water in experimental metabolic syndrome.

Background: Metabolic Syndrome (MS) is a widespread pathological condition, a group of interconnected metabolic disorders that contribute to the development of a number of severe noncommunicable diseases. Natural mineral waters of various compositions are widely used in the correction of MS. Their biological activity and specificity of action is associated with the presence of specific components (micronutrients, biologically active substances).

[PREDICTORS OF ATHEROSCLEROSIS: NEW DEVELOPMENTS].

The article describes known atherosclerosis predictors of endothelial origin, which are diagnostic criteria for identifying's early stages of atherosclerosis, and can prevent the development of this disease and are used to monitor the effectiveness of the therapy The authors analyzed the possibility of using heparin as an early marker of atherosclerosis, based on the fact that the inhibition of lipoprotein lipase activity due hyperheparinemia resulting from depletion of mast cells due to endothelial dysfunction, leads to the disorders of lipid transporting system in the form of the resistant hyperlipidemia with the phenomena of dyslipidemia.

[THE DYNAMICS OF THE INCIDENCE OF OPPORTUNISTIC INFECTIONS AND SOMATIC DISEASES HIV-INFECTED PATIENTS WHO RECEIVED INPATIENT TREATMENT IN 2006-2011].

To the article a brief historical review and modern data are driven about the state of HIV-infection in the Odessa area, morbidity of HIV is analysed--the infected patients, passing treatment in stationary section of the Odessa regional centre from a prophylaxis and fight against AIDS during the last six year, drawn conclusion about efficiency of introduction of potent antiretroviral therapy.

[Comparative assessment of nephroprotective properties of potassium and calcium channel modulators in experimental renal injury].

The experiments in white laboratory rats have shown that a single intragasrtric administration of the new fluorine-containing potassium channel opener flocalin in a dose of 5 mg/kg in the initial stage of sublimate nephropathy increased the glomerular filtration rate, reduced creatininemia, increased urinary creatinine excretion, and decreased proteinuria. Under similar conditions, the administration of the calcium channel blocker diltiazem in a dose of 5 mg/kg (intragasrtric) showed a less pronounced antiproteinuric effect as compared to that of flocalin. A comparative assessment of the influence of flocalin and diltiazem on the basic renal function markers demonstrated predominant nephroprotective effect of flocalin in the treatment of acute toxic nephropathy.

[Chlorine dioxide as an agent for optimization of drinking water preparation].

The paper deals with the important urgent problem in the provision of epidemiological drinking water. It considers the chemical, biological, toxicological, technological, environmental, and economic aspects of the use of chlorine dioxide as a highly effective disinfecting and oxidizing agent in water purification and decontamination processes. The authors present the results of their own studies.

[Effect of sodium-rich diet and captopril on the functional state of kidney in rats with experimental hyperthyreosis].

The administration of thyroxin (10 microg/100 g body weight, 7 days) in rats leads to an increase in the renal excretion of proteins and nitrates. Under the conditions of hypo- and normosodium diet, thyroxin decreased the rate of glomerular filtration. Hypersodium diet and captopril increased the rate of glomerular filtration in rats with experimental hyperthyreosis.

[Characteristics of the kidney functional state after a single dose of thyroxine in white rats].

A 50 mcg/100 g b.w. single dose of thyroxine was injected to non-inbred white rat males with body mass 140-180 g in conditions of 5% water and osmotic (3% solution of sodium chloride) load, then renal function was studied.

[Effect of ascorbic acid on the renal transport of endogenous nitrates and nitrites in humans].

Effect of ascorbic acid on the renal excretion of endogenous nitrates and nitrites under aqueous-salt load was studied in practically healthy females. The administration of ascorbic acid in a dose of 10 mg/kg body weight under these conditions favored a decrease in the renal excretion of endogenous nitrates due to modulation of their renal clearance mechanism.

[Renal mechanisms of the osmotic homeostasis maintenance on a background of the salt test].

Mechanisms of the renal function were studied in white mice subjected to water and hyperosmotic tests. Excretion of excess osmotically active substances appeared to be affected by as modulation of the tubular transport, so intensification of the glomerular filtration through activation of the functional kidney reserve and involvement of renal nitrogen oxide.

[Determination of nonmetabolized antipyrine in human urine].

A method for evaluating the renal clearance of antipyrine is proposed. The analyses were performed for a group of healthy females of reproductive age. The renal clearance of nontransformed antipyrine is found to be significant and the basic indices of renal activity (diuresis, creatinine excretion) are correlated with the drug concentration in saliva.

[Role of nitric oxide in tumor growth].

This review article will analyze the role of nitric oxide in antiblastomous organism resistance, in particular some mechanisms of NO-mediated apoptosis in different cells and NO involvement in etiological mechanisms as well as tumor growth promotion. The possible mechanisms of nitric oxide dual effect are discussed. The data about NO as a mediator in different methods of cancer treatment are given.

[Operative intervention as a factor provoking the ulcer formation process in patients suffering from chronic gastritis type B].

The article presents 27 cases of ulcer formation in the duodenal bulb that occurred in 8.3 +/- 0.13 days after an operative intervention carried out because of the calculous cholecystitis and coccygeal cyst.

[Altered renal function in acute sodium nitrite intoxication experiment].

In experiments on non-inbred albino rats, intoxication was reproduced with 1% aqueous sodium nitrite solution, which was rated by the degree of hemic hypoxia (HH). The findings suggest that changes in renal functions (osmo-regulating, sodium-regulating) occur due to the development of mild HH, by increasing as hypoxia deteriorates. Decreased glomerular filtration and proteinuria, which are concomitantly detected, point to their mixed glomerulotubular pattern of renal lesion in nitrite intoxication.

[Classification of renal failure].

The authors analyze the data available in the literature on acute and chronic renal failure (ARF and CRF, respectively). The mechanisms of their development (common and distinctive) are pathogenetically assessed and the functional reserve of the kidneys is determined. The phasic character of development of renal failure (compensation, subcompensation and decompensation) is pathogenetically substantiated.

[Method to determine nitrite and nitrate ecologic load on humans].

To evaluate ecologic load with nitrite-nitrate ions, the authors suggest determining the diurnal excretion and then excluding contribution of the endogenous compounds.

[Activity of gastric mucosal NO synthase in duodenal ulcer].

The paper covers the results of 32 endoscopic studies. The D. E.