Publications by authors named "Gozde Guven"
Article Synopsis
- PTEN and PIK3CA mutations are common in several cancers and loss of PTEN leads to increased activity of the p110β isoform of the PI3K pathway.
- The study found that the enzyme SQLE, important for cholesterol production, is upregulated in PTEN-deficient prostate tumors, and its levels are connected with PI3K activation.
- Targeting cholesterol biosynthesis alongside hormone receptor signaling may enhance treatment effectiveness for hormone-resistant prostate and breast cancers that lack PTEN.
With their unique capabilities of self-renewal and differentiation into three germ layers, mouse embryonic stem cells (mESCs) are widely used as an in vitro cellular model for early mammalian developmental studies. mESCs are traditionally cultured in high-serum and LIF-containing medium on a growth-deficient mouse embryonic fibroblast layer. A more recent culturing system with two inhibitors (for GSK3β (CHIR99021) and MEK1/2 (PD0325901)) and LIF enables the derivation of mESC lines from various mouse strains.
View Article and Find Full Text PDFCell division and death play an important role in embryonic development. Cell specialization is accompanied with slow proliferation and quiescence. Cell death is important for morphogenesis.
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