Publications by authors named "Gozde Erdemir"
Article Synopsis
- - This report details a pediatric case of MPPH syndrome, a rare neurodevelopmental disorder linked to gene variants, specifically a unique CCND2 variant in this patient that caused serious neurological issues.
- - The patient showed significant prenatal abnormalities, such as ventriculomegaly and polymicrogyria, and developed infantile spasms which were eventually managed with topiramate after prednisone failed.
- - The findings emphasize the need for prompt genetic testing and neuroimaging for accurate diagnosis and management of MPPH syndrome, suggesting that early intervention could lead to better developmental outcomes.
To conduct a systematic review of the literature regarding rates and predictors of favorable seizure outcome after resective surgery for epileptic spasms (ES) in pediatric patients. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses standards were followed. We searched PubMed, EMBASE, and Cochrane CENTRAL for articles published on the prevalence or incidence of epileptic spasm since 1985.
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- Epileptic spasms are a type of seizure found in infants and young children, often linked to a syndrome that can cause developmental delays and declines due to abnormal brain activities seen in EEGs.
- Early detection and treatment of these spasms are crucial to improving children's outcomes, with hypsarrhythmia patterns playing a key role in diagnosis.
- Some patients may have treatable causes for their spasms that can be identified with brain imaging, though surgical decisions may not always require invasive EEG monitoring.
Electroclinical Features in Epilepsy Surgery Candidates With Epileptic Spasms.
J Clin Neurophysiol
November 2022
Electroclinical features in surgical candidates with epileptic spasms differ significantly from the other focal epilepsy phenotypes. EEG findings tend to be more diffuse and less localizing in children with epileptic spasms. These are illustrated with five case studies to highlight three different categories of findings on interictal and ictal EEG: lateralizing , nonlateralizing , and false lateralizing .
View Article and Find Full Text PDFObjective: Prior surgical series in children with drug-resistant epileptic spasms have reported use of intracranial EEG monitoring in up to two-third of patients. We report outcome after epilepsy surgery for drug-resistant epileptic spasms in a cohort of children without the use of intracranial EEG monitoring in any of the patients.
Methods: Medical records of all consecutive children aged 5 years or under who had epilepsy surgery for epileptic spasms at Cleveland Clinic between 2000 and 2018 were reviewed.
Objective: Drug-resistant epilepsy (DRE) during the first few months of life is challenging and necessitates aggressive treatment, including surgery. Because the most common causes of DRE in infancy are related to extensive developmental anomalies, surgery often entails extensive tissue resections or disconnection. The literature on "ultra-early" epilepsy surgery is sparse, with limited data concerning efficacy controlling the seizures, and safety.
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