A dose-response trial of nebivolol in essential hypertension.

A double-blind placebo-controlled dose-response trial of nebivolol, a cardioselective beta-blocking drug which also induces endothelium-dependent dilatation via nitric oxide, has been performed. Nebivolol reduced blood pressure (BP) in a dose dependent way, and was shown to be effective given once daily, without appreciable differences between peak and trough drug levels. There was no postural component to the BP fall.

Gastroesophageal reflux, as measured by 24-hour pH monitoring, in 509 healthy infants screened for risk of sudden infant death syndrome.

Continuous long-term esophageal pH monitoring has become the preferred test to quantify acid gastroesophageal reflux. Because reflux to a limited extent is physiologic, the determination of optimal thresholds to separate normal from abnormal reflux is mandatory. Esophageal pH was measured during 24 hours in 509 healthy thriving infants, aged 3 days to 1 year, using a glass microelectrode with an external reference electrode connected to a portable recorder.

Comparative study of glass and antimony electrodes for continuous oesophageal pH monitoring.

Oesophageal pH monitoring data are influenced by numerous patient or technique related factors, or both. In this study, data recorded with glass microelectrodes or antimony electrodes, both with external cutaneous Ag/AgCl reference electrodes, connected to two different recording devices are compared. Pearson correlation coefficients regarding the reflux index (% of the investigation time with a pH less than 4) ranged from poor to excellent (0.

Reproducibility of continuous 24 hour oesophageal pH monitoring in infants and children.

The reproducibility of 24 hour oesophageal pH monitoring was studied in 30 infants and children including the proportions of the investigation time with a pH less than 4 (reflux index), the number of episodes with a pH less than 4 or lasting longer than five minutes, and the duration of the longest episodes with a pH less than 4. Twenty four hour pH monitoring was performed using identical equipment on two consecutive days under similar conditions. Pearson correlation coefficients range from 0.

Do esophageal pH monitoring data depend on recording equipment and probes?

Esophageal pH monitoring data are influenced by numerous patient- and/or technical equipment-related factors. In this study, data obtained with 10 pH recording devices of two different companies and 10 pH glass-microelectrodes with an external reference electrode of one company, calibrated by different persons, were compared. Pearson correlation coefficients regarding the reflux index (the percentage of the investigation time with a pH less than 4) ranged from 0.

Itraconazole in the treatment of human mycoses: review of three years of clinical experience.

During the first three years of clinical investigation of itraconazole, more than 1,000 patients with mycoses were treated with the drug. Almost 50% were women with vaginal candidosis; a dosage of 200 mg per day for three days appeared to be optimal for their treatment. Several treatment regimens were tested for pityriasis versicolor; the minimum total dose necessary for optimal results was 1 g.