Spatio-temporal analysis of extreme air pollution and risk assessment.

Extreme air pollution poses global health and environmental threats, necessitating robust policy interventions. This study first analyses the surface mass concentration of major aerosols (such as black carbon, organic carbon, dust, sea salts, and sulphates) to estimate global PM concentrations from 1980 to 2023. The developed model-estimated PM database was validated against data from 526 cities worldwide, showing strong accuracy, with RMSE, r, and R values of 7.

Novel antibodies detect nucleocytoplasmic O-fucose in protist pathogens, cellular slime molds, and plants.

Cellular adaptations to change often involve post-translational modifications of nuclear and cytoplasmic proteins. An example found in protists and plants is the modification of serine and threonine residues of dozens to hundreds of nucleocytoplasmic proteins with a single fucose (O-Fuc). A nucleocytoplasmic O-fucosyltransferase (OFT) occurs in the pathogen , the social amoeba , and higher plants, where it is called Spy because mutants have a spindly appearance.

Identification of new targets for the diagnosis of cysts (four) and trophozoites (one) of the eye pathogen .

Unlabelled: , which are free-living amoebae, cause corneal inflammation (keratitis) and blindness, if not diagnosed and effectively treated. While trophozoites adhere to and damage the cornea, cysts, the walls of which contain cellulose and have two layers connected by conical ostioles, are the diagnostic form by microscopy of the eye or of corneal scrapings. We recently used structural and experimental methods to characterize cellulose-binding domains of Luke and Leo lectins, which are abundant in the inner layer and ostioles.

Torsemide in Edema Associated with Chronic Kidney Disease.

Torsemide is a loop diuretic used to manage edema associated with chronic kidney disease (CKD) and acute kidney injury (AKI). It acts by inhibiting sodium and chloride ions reabsorption in the ascending limb of the loop of Henle, thereby increasing urine output and reducing fluid accumulation. Compared to other diuretics, torsemide has an extended duration of action, higher bioavailability, and its elimination route is primarily through the hepatic route, making it effective in patients with CKD and AKI.

Transforming air pollution management in India with AI and machine learning technologies.

A comprehensive approach is essential in India's ongoing battle against air pollution, combining technological advancements, regulatory reinforcement, and widespread societal engagement. Bridging technological gaps involves deploying sophisticated pollution control technologies and addressing the rural-urban disparity through innovative solutions. The review found that integrating Artificial Intelligence and Machine Learning (AI&ML) in air quality forecasting demonstrates promising results with a remarkable model efficiency.

Cellulose binding and the timing of expression influence protein targeting to the double-layered cyst wall of .

The cyst wall of the eye pathogen contains cellulose and has ectocyst and endocyst layers connected by conical ostioles. Cyst walls contain families of lectins that localize to the ectocyst layer (Jonah) or the endocyst layer and ostioles (Luke and Leo). How lectins and an abundant laccase bind cellulose and why proteins go to locations in the wall are not known and are the focus of the studies here.

EEG based functional connectivity in resting and emotional states may identify major depressive disorder using machine learning.

Objective: Disrupted brain network connectivity underlies major depressive disorder (MDD). Altered EEG based Functional connectivity (FC) with Emotional stimuli in major depressive disorder (MDD) in addition to resting state FC may help in improving the diagnostic accuracy of machine learning classification models. We explored the potential of EEG-based FC during resting state and emotional processing, for diagnosing MDD using machine learning approach.

Correlation of oxygenation indices in invasive mechanical ventilated adult patients.

Background: Mechanical ventilation is essential for managing acute respiratory failure, but traditional methods of assessing oxygenation, like the PaO2/FiO2 ratio, pose challenges due to invasiveness and cost.

Objective: This single-centre prospective observational study aimed to assess the potential of the non-invasive Oxygen Saturation Index (OSI), utilising SpO2 measurements, to diagnose hypoxemia in mechanically ventilated adults. The study sought to establish correlations between OSI, oxygenation index (OI), PaO2/FiO2 ratio and SpO2/FiO2 ratio.

Percentage of patients shifting to another treatment modality: An experience-guided decision.

Objective: This study aimed to assess the frequency with which orthodontic patients decided to shift to another type of orthodontic appliance, among conventional metal brackets, ceramic brackets, lingual brackets and clear aligner, based on their personal experiences of pain, ulcers, bad breath, hygiene issues and social difficulties.

Material And Methods: This study comprises of patients seeking orthodontic treatment. The sample (n = 500; age group = 19-25 years) was divided equally into four groups based on the treatment modality: conventional metal brackets, ceramic brackets, lingual brackets and clear aligner.

Alba6 exhibits DNase activity and participates in stress response.

Alba domain proteins, owing to their functional plasticity, play a significant role in organisms. Here, we report an intrinsic DNase activity of PfAlba6 from , an etiological agent responsible for human malignant malaria. We identified that tyrosine28 plays a critical role in the Mg driven 5'-3' DNase activity of PfAlba6.

Prevalence and clinical correlates of co-morbid attention deficit hyperactivity disorder in euthymic adults with bipolar disorder: A cross-sectional study.

Background: Bipolar disorders (BDs) are co-morbid with attention deficit hyperactivity disorder (ADHD), making diagnosis and management more difficult and associated with poorer outcomes. So, this study was planned to find the prevalence and clinical implication of co-morbid ADHD in BD.

Materials And Methods: In this cross-sectional study, a total of 110 euthymic BD patients were taken.

Transboundary hazard and downstream impact of glacial lakes in Hindu-Kush Karakoram Himalayas.

Glacial Lake Outburst Floods (GLOFs) can generate catastrophic flash floods when the damming structure is breached or overtopped. Some of these glacial lakes are located in transboundary regions where floods originating from the lake in one country could inundate a neighboring country, devastating the population and infrastructure of both nations and influencing socio-political relationships. Therefore, assessing the lakes' hazard is crucial.

Characterizing the spatio-temporal distribution, detection, and prediction of aerosol atmospheric rivers on a global scale.

Aerosol Atmospheric Rivers (AARs) are elongated and narrow regions that carry high concentrations of aerosols (tiny particles suspended in the atmosphere) across large distances, exerting effects on both air quality and human health (Chakraborty et al., 2021, 2022). Monitoring and modeling these aerosols present distinct challenges due to their dynamic nature and complex interactions within the atmosphere.

Spatiotemporal-based automated inundation mapping of Ramsar wetlands using Google Earth Engine.

Wetlands are one of the most critical components of an ecosystem, supporting many ecological niches and a rich diversity of flora and fauna. The ecological significance of these sites makes it imperative to study the changes in their inundation extent and propose necessary measures for their conservation. This study analyzes all 64 Ramsar sites in China based on their inundation patterns using Landsat imagery from 1991 to 2020.

Exaggerated response to pattern reversal visual evoked potential among migraineurs.

Objective: Visual evoked potential recording has reported ambiguous results among migraineurs, thus the present study explored the association of check-size and reversal rates on the latency and amplitude of pattern reversal VEP among migraineurs.

Method And Material: Monocular VEP responses for both eyes were recorded in 133 migraineurs and 111 controls. Checkerboard pattern with phase reversal frequency of 0.

The Effect of Difference in Word Order on Semantic Processing in Hindi-English Bilinguals.

Background: The typology of word order in Hindi (Subject-Object-Verb, SOV) differs from that of English (Subject-Verb-Object, SVO). Bilinguals whose two languages have conflicting word order provide a unique opportunity to understand how word order affects language processing. Earlier behavioural and event-related brain potential (ERP) studies with Spanish-Basque bilinguals showed longer reading times and more errors in the comprehension of OSV sentences than SOV sentences in Basque language, indicating that non-canonical word orders (OSV) were difficult to process than canonical word order (SOV).