Recurrent genetic abnormalities detected by FISH in adult B ALL and association with hematological parameters.

Background: Recurrent genetic abnormalities influence prognosis in B lymphoblastic leukemia. BCR-ABL rearrangement is associated with higher leukocyte counts and older age at presentation. Among adults, BCR -ABL - is the commonest recurrent abnormality whereas, IgH rearrangements are rare.

EGFR mutations and ROS1 and ALK rearrangements in a large series of non-small cell lung cancer in South India.

Background: Driver mutations are seen in 80% of lung adenocarcinomas, and they influence prognosis and choice of therapy.

Aim: Aim of this study was to analyse the frequency of epidermal growth factor receptor (EGFR) mutations, ALK and ROS1 rearrangements and their association with age and gender in non-small cell lung cancer reported from a tertiary care center in South India.

Methods: Tumors from patients with non-small cell carcinoma of lung were evaluated for EGFR mutations, ALK and ROS1 rearrangements and their association with age and gender were studied.