Concentration-dependent mode of binding of drug oxatomide with DNA: multi-spectroscopic, voltammetric and metadynamics simulation analysis.

The interaction between antihistaminic drug oxatomide () and calf-thymus DNA (CT-DNA) has been investigated in a physiological buffer (pH 7.4) using UV-Vis, fluorescence, H NMR and circular dichroism spectral techniques coupled with viscosity measurements, KI quenching, voltammetry and molecular modeling studies. binds with CT-DNA in a concentration-dependent manner.

Highly selective turn-on fluorescent probe for detection of cyanide in water and food materials.

A naphthoquinone-imine based fluorescent probe (R) has been synthesized and characterized by NMR and mass spectral techniques. The receptor shows high selectivity towards cyanide in water in the presence of other competitive anions with an instantaneous colour change from non-emissive to green under UV light. The turn-on fluorescence is due to deprotonation of three hydroxyl groups by cyanide ions as evidenced from H NMR titration experiment.

Application of Various Statistical Models to Explore Gene-Gene Interactions in Folate, Xenobiotic, Toll-Like Receptor and STAT4 Pathways that Modulate Susceptibility to Systemic Lupus Erythematosus.

Introduction: In view of our previous studies showing an independent association of genetic polymorphisms in folate, xenobiotic, and toll-like receptor (TLR) pathways with the risk for systemic lupus erythematosus (SLE), we have developed three statistical models to delineate complex gene-gene interactions between folate, xenobiotic, TLR, and signal transducer and activator of transcription 4 (STAT4) signaling pathways in association with the molecular pathophysiology of SLE.

Methods: We developed additive, multifactor dimensionality reduction (MDR), and artificial neural network (ANN) models.

Results: The additive model, although the simplest, suggested a moderate predictability of 30 polymorphisms of these four pathways (area under the curve [AUC] 0.