Publications by authors named "Govindaraj Ellur"
Article Synopsis
- Severe thermal skin burns are made worse by inflammation and cell death, leading to slower healing and increased complications.
- Researchers repurposed the FDA-approved drug 4-aminopyridine (4-AP) to enhance burn healing in mice, finding it significantly reduced inflammatory markers and promoted healing processes.
- 4-AP's effects included reducing cell apoptosis, promoting blood vessel formation, and enhancing fibroblast transformation, suggesting it could be an effective treatment for improving burn wound recovery.
Severe thermal skin burns are complicated by inflammation and apoptosis, which delays wound healing and contributes to significant morbidity. Diverse treatments demonstrate limited success with mitigating these processes to accelerate healing. Agents that alter cell behavior to improve healing would alter treatment paradigms.
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