Base-promoted triple cleavage of CClBr: a direct one-pot synthesis of unsymmetrical oxalamide derivatives.

We present a novel, eco-friendly and one-pot approach for synthesizing unsymmetrical oxalamides with the aid of dichloroacetamide and amine/amides in the presence of CBr in a basic medium. The use of water as a potent supplement for the oxygen atom source and the detailed mechanism have been disclosed. Moreover, the protocol involves triple cleavage of CClBr and the formation of new C-O/C-N bonds, with the advantage of achieving selective bromination using CBr with good to excellent yield under mild conditions.

A response surface model to examine the reactive red 239 sorption behaviors on Rhizoclonium hieroglyphicum: isotherms, kinetics, thermodynamics and toxicity analyses.

The present study is an attempt to investigate the potentiality of Rhizoclonium hieroglyphicum in the removal of reactive red 239 (RR239) from aqueous solution and to assess the toxicity of the treated dye solution. Optimisation of the process variables namely dye and biosorbent concentrations, pH, temperature and incubation time for RR239 removal was performed using Response Surface Methodology (RSM) assisted Box Behnken Design (BBD) model. The recycling and regeneration efficiency of the dye adsorbed alga was evaluated using different eluents under optimized conditions.

Distribution and Functional Analyses of Mutations in Spike Protein and Phylogenic Diversity of SARS-CoV-2 Variants Emerged during the Year 2021 in India.

Introduction: Prolonged COVID-19 pandemic accelerates the emergence and transmissibility of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) variants through the accumulation of adaptive mutations. Particularly, adaptive mutations in spike (S) protein of SARS-CoV-2 leads to increased viral infectivity, severe morbidity and mortality, and immune evasion. This study focuses on the phylodynamic distribution of SARS-CoV-2 variants during the year 2021 in India besides analyzing the functional significance of mutations in S-protein of SARS-CoV-2 variants.

FeCl-Catalyzed Decyanative [4 + 2] Annulation of α-Aminonitriles with Alkynes: Access to 2,4-Diaryl Quinolines in Batch and Continuous-Flow Processes.

FeCl-catalyzed decyanation of α-aminonitriles followed by a [4 + 2] annulation with terminal alkynes has been developed to synthesize 2,4-diaryl quinolines. A broad range of aniline, aldehyde, and arylacetylene derivatives were well tolerated to access 2,4-diaryl quinolines in moderate to good yields. The control experiment studies suggested that the reaction proceeds through a nonradical pathway involving Povarov-type [4 + 2] annulation from the generated iminium species.

Iodine-Promoted Oxidative Cyclization of Acylated and Alkylated Derivatives from Epoxides toward the Synthesis of Aza Heterocycles.

A new method for directly synthesizing acylated and alkylated quinazoline derivatives by the epoxide ring-opening reaction in the presence of I/DMSO with 2-aminobenzamide is described herein. The developed mild protocol is efficient and displays a wide variety of functional group tolerance and substrate-controlled high selectivity, and the application of a continuous flow technique allows for faster reaction time and higher yields. Moreover, the robustness of the method is applicable in gram-scale synthesis.

The utility of inflammatory and endothelial factors in the prognosis of severe dengue.

Background: Severe dengue is associated with a considerable risk of mortality, and there is currently a lack of appropriate prognostic biomarkers to predict its severity. Pathogenesis of severe dengue is characterized by overt inflammation, endothelial activation, and increased vascular permeability. The current study investigates the utility of endothelial, inflammatory, and vascular permeability factors as biomarkers to identify dengue severity, which could improve disease prognosis and management.

Serum levels of matrix metalloproteinases as prognostic markers for severe dengue with plasma leakage.

Background: Plasma leakage is a major pathogenic manifestation of severe dengue and is a precursor of life-threatening complications associated with dengue. Accumulating evidence indicates the role of Matrix Metalloproteinases (MMPs) in mediating vascular permeability and plasma leakage following induction by the dengue virus. This study aims to investigate the utility of MMP-2, MMP-3, and MMP-9 in predicting the severity of dengue infection and further explore the relationship of these markers with the pathogenic factors associated with plasma leakage.

Metal-Free N-H/C-H Carbonylation by Phenyl Isocyanate: Divergent Synthesis of Six-Membered -Heterocycles.

We disclose a method using phenyl isocyanate to synthesize carbonyl-containing -heterocycles. The metal-free novel approach for both N-H and C-H carbonylation processes was successfully refined, delivering a range of synthetically valuable derivatives of quinazoline-2,4(1,3)-dione, 2-benzo[] [1,2,4] thiadiazin-3(4)-one 1,1-dioxide, and pyrrolo[1,2-] quinoxalin-4(5)-one. The protocol features broad substrates with diverse reactions suitable for excellent yields, mild conditions, and good functional group compatibility.

A causality analysis of risks to perishable product supply chain networks during the COVID-19 outbreak era: An extended DEMATEL method under Pythagorean fuzzy environment.

In nowadays world, firms are encountered with many challenges that can jeopardize business continuity. Recently, the coronavirus has brought some problems for supply chain networks. Remarkably, perishable product supply chain networks, such as pharmaceutical, dairy, blood, and food supply chains deal with more sophisticated situations.

Epitope Identification and Designing a Potent Multi-epitope Vaccine Construct against SARS-CoV-2 Including the Emerging Variants.

Introduction: The emergence of a novel coronavirus in China has turned into a SARS-CoV-2 pandemic with high fatality. As vaccines are developed through various strategies, their immunogenic potential may drastically vary and thus pose several challenges in offering immune responses against the virus.

Methods: In this study, we adopted an immunoinformatics-aided approach for developing a new multi-epitope vaccine construct (MEVC).

Resource planning strategies for healthcare systems during a pandemic.

We study resource planning strategies, including the integrated healthcare resources' allocation and sharing as well as patients' transfer, to improve the response of health systems to massive increases in demand during epidemics and pandemics. Our study considers various types of patients and resources to provide access to patient care with minimum capacity extension. Adding new resources takes time that most patients don't have during pandemics.

Phylodynamic Pattern of Genetic Clusters, Paradigm Shift on Spatio-Temporal Distribution of Clades, and Impact of Spike Glycoprotein Mutations of SARS-CoV-2 Isolates from India.

Introduction: The COVID-19 pandemic is associated with high morbidity and mortality, with the emergence of numerous variants. The dynamics of SARS-CoV-2 with respect to clade distribution is uneven, unpredictable and fast changing.

Methods: Retrieving the complete genomes of SARS-CoV-2 from India and subjecting them to analysis on phylogenetic clade diversity, Spike (S) protein mutations and their functional consequences such as immune escape features and impact on infectivity.

From Sustainable Global Value Chains to Circular Economy-Different Silos, Different Perspectives, but Many Opportunities to Build Bridges.

A growing interest in the circular economy concept has pushed the discourse in various management-related disciplines beyond established boundaries, with calls to better address how such a model may be developed in a world of global value chains. Still, the conventional linear economy model continues to dominate business, society, and research. While the concept of better connecting physical output and input flows at multiple production or consumption levels is becoming more accepted, it remains unclear how to make this happen while ensuring that sustainability targets are met or exceeded.

Artificial intelligence-based human-centric decision support framework: an application to predictive maintenance in asset management under pandemic environments.

Pandemic events, particularly the current Covid-19 disease, compel organisations to re-formulate their day-to-day operations for achieving various business goals such as cost reduction. Unfortunately, small and medium enterprises (SMEs) making up more than 95% of all businesses is the hardest hit sector. This has urged SMEs to rethink their operations to survive through pandemic events.

Unlocking Amides through Selective C-N Bond Cleavage: Allyl Bromide-Mediated Divergent Synthesis of Nitrogen-Containing Functional Groups.

We report a new set of reactions based on the unlocking of amides through simple treatment with allyl bromide, creating a common platform for accessing a diverse range of nitrogen-containing functional groups such as primary amides, sulfonamides, primary amines, -acyl compounds (esters, thioesters, amides), and -sulfonyl esters. The method has potential industrial applicability, as demonstrated through gram-scale syntheses in batch and in a continuous flow system.

Prioritising risk mitigation strategies for environmentally sustainable clothing supply chains: Insights from selected organisational theories.

Recent outbreak of COVID-19 pandemic has provided strong impetus to supply chain resilience research. In a volatile and uncertain business environment, resilience can be incorporated by developing and implementing effective risk mitigation strategies. In this research, risk mitigation strategies for environmentally sustainable clothing supply chain have been prioritised by considering their efficacy to mitigate various risks.

Medical waste management during coronavirus disease 2019 (COVID-19) outbreak: A mathematical programming model.

Municipal solid waste (MSW) directly impacts community health and environmental degradation; therefore, the management of MSW is crucial. Medical waste is a specific type of MSW which is generally divided into two categories: infectious and non-infectious. Wastes generated by coronavirus disease 2019 (COVID-19) are classified among infectious medical wastes; moreover, these wastes are hazardous because they threaten the environment and living organisms if they are not appropriately managed.

Investigation of carbonaceous materials electrosorption attributes and its performance for capacitive deionization process within the presence of humic acid.

This present investigation emphasizes on pros and cons of humic acid (HA) on electrosorption behaviour and performance efficiency of capacitive deionization (CDI) process. Electrosorptive removal of HA was examined by lab scale CDI flow cell under 100 ppm NaSO as a supporting electrolyte. In addition, the electrosorption capacitance and desalination performances were also evaluated through cyclic voltammetry studies.

A mathematical programming approach for equitable COVID-19 vaccine distribution in developing countries.

Developing countries scramble to contain and mitigate the spread of coronavirus disease 2019 (COVID-19), and world leaders demand equitable distribution of vaccines to trigger economic recovery. Although numerous strategies, including education, quarantine, and immunization, have been used to control COVID-19, the best method to curb this disease is vaccination. Due to the high demand for COVID 19 vaccine, developing countries must carefully identify and prioritize vulnerable populations and rationalize the vaccine allocation process.

Issues and solutions of electronic waste urban mining for circular economy transition: An Indian context.

The rapid consumption of advanced e-products has intensified problems for the linear economy; constantly diminishing natural resources employed in production processes have created a need of recycle and reuse. Although the transition to a circular economy proposes to end the loop of e-products, it needs the application of processes such as urban mining to recover resources as secondary raw material. The present study intends to examine the issues and challenges of electronic waste urban mining (EWUM) in India that need to be assessed for the development of a sustainable economy.

Quantitative proteome profiling stratifies fibroepithelial lesions of the breast.

Breast fibroepithelial lesions (FELs) include heterogeneous pathological tumors, involving indolent fibroadenoma (FAD) to potentially aggressive phyllodes tumors (PTs). The current grading system remains unreliable in differentiating these tumors due to histological heterogeneity and lack of appropriate markers to monitor the sudden and unpredictable malignant transformation of PTs. Thus, there exists an imminent need for a marker-based diagnostic approach to augment the conventional histological platform that could lead to accurate diagnosis and distinction of FELs.

Ring Opening/Site Selective Cleavage in Acyl Glutarimide to Synthesize Primary Amides.

A LiOH-promoted hydrolysis selective C-N cleavage of twisted -acyl glutarimide for the synthesis of primary amides under mild conditions has been developed. The reaction is triggered by a ring opening of glutarimide followed by C-N cleavage to afford primary amides using 2 equiv of LiOH as the base at room temperature. The efficacy of the reactions was considered and administrated for various aryl and alkyl substituents in good yield with high selectivity.

Electrochemical recovery of H and nutrients (N, P) from synthetic source separate urine water.

This study examined an electrochemical method of H production and nutrient recovery from synthetic source separated urine (SSU). The efficacy of H production was examined through hydrogen recovery experiments (HRE) using Ni foam electrodes. Similarly, nutrient (N and P) recovery was also examined in post-nutrient recovery experiments (NRE) with sacrificial Mg electrodes.