Induction and preliminary characterization of neoplastic pulmonary nodules in a transgenic pig model.

Objectives: Lung cancer models in large animals are lacking. Oncopigs are transgenic pigs that carry both KRAS and TP53 Cre-inducible mutations. This study aimed to develop and histologically characterize a swine model of lung cancer that could serve for preclinical studies evaluating locoregional therapies.