Glaucoma monitoring in a clinical setting: glaucoma progression analysis vs nonparametric progression analysis in the Groningen Longitudinal Glaucoma Study.

Objective: To compare prospectively 2 perimetric progression detection algorithms for glaucoma, the Early Manifest Glaucoma Trial algorithm (glaucoma progression analysis [GPA]) and a nonparametric algorithm applied to the mean deviation (MD) (nonparametric progression analysis [NPA]).

Methods: Patients with a reproducible glaucomatous visual field defect at baseline in at least 1 eye were followed up prospectively using perimetry (Humphrey field analyzer 30-2 Swedish interactive thresholding algorithm). Classifications by GPA and by NPA at the end of the follow-up period were compared.

The Groningen Longitudinal Glaucoma Study. II. A prospective comparison of frequency doubling perimetry, the GDx nerve fibre analyser and standard automated perimetry in glaucoma suspect patients.

Purpose: We aimed to determine prospectively the incidence of abnormal test results on frequency doubling perimetry (FDT), the nerve fibre analyser (GDx) and standard automated perimetry (SAP) in a cohort of glaucoma suspect patients with normal findings for all these tests at baseline.

Methods: Seventy glaucoma suspect patients were followed prospectively for 4 years with SAP (Humphrey field analyser 30-2 SITA Fast), FDT (C-20 full-threshold) and GDx (Version 2.010) in a clinical setting.

Influence of test reliability on the screening performance of frequency-doubling perimetry.

Purpose: To investigate the influence of test reliability on the screening performance of frequency-doubling perimetry (FDT).

Design: Cross-sectional study.

Methods: FDT sensitivity and specificity were calculated three times using three different strategies for handling unreliable (that is, >0 reliability indices outside normal limits) and unfeasible (that is, could not be completed) tests in 452 glaucoma patients from our outpatient department and 237 healthy subjects recruited outside the hospital.

Strategies for improving the diagnostic specificity of the frequency doubling perimeter.

Purpose: To evaluate various strategies designed to improve the specificity of the interpretation of results obtained with the frequency doubling technology perimeter (FDT) used in the full-threshold mode.

Methods: Three different strategies were compared using data from 452 glaucoma patients and 237 healthy subjects: combining several FDT parameters from a single test, combining the FDT test with a GDx test, and confirming an abnormal FDT test result with a repeat test.

Results: Confirming an abnormal FDT test result with a repeat test yielded a specificity increase of 0.

The Groningen Longitudinal Glaucoma Study. I. Baseline sensitivity and specificity of the frequency doubling perimeter and the GDx nerve fibre analyser.

Purpose: To describe the baseline data of a large cohort of patients included for follow-up with perimetry using the frequency doubling technique (FDT) and with quantification of the retinal nerve fibre layer as assessed by GDx, and to calculate the sensitivity and specificity of both devices from these baseline data.

Methods: Regular visitors to our glaucoma service were included. All subjects were followed for at least 4 years with FDT in full-threshold mode, GDx and conventional perimetry.

An evaluation of algorithms designed to classify the results from frequency doubling perimetry.

All previously published algorithms for the interpretation of frequency doubling perimetry test results were compared in full-threshold mode in a large group of glaucoma patients (n = 452) and normal subjects (n = 237). Areas under the receiver-operating characteristic (ROC) curve ranged from 0.86 to 0.

Frequency doubling perimetry screening mode compared to the full-threshold mode.

The diagnostic performance of the frequency doubling perimetry (FDT) C20-1 screening mode was compared to that of the C20 full-threshold mode. For the number of defects p < 1% in the total deviation plot, both modes appeared to perform similarly in terms of sensitivity, specificity, and area under the receiver-operating characteristic (ROC) curve. Different cut-off points should be applied for both modes to obtain equal sensitivity and specificity values, and - related to that - for most subjects more defects were found in full-threshold mode than in screening mode.

Learning effect, normal range, and test-retest variability of Frequency Doubling Perimetry as a function of age, perimetric experience, and the presence or absence of glaucoma.

The learning effect for several different Frequency Doubling Perimetry parameters was studied in full threshold mode in a large group of patients (n = 342) of various ages, with and without perimetric experience, and with and without glaucoma. A significant learning effect was only found for the mean deviation (MD) in aged normals without perimetric experience. The median of MD increased for both OD (from +0.