Pediatric Cardiac Critical Care: A Vital Link in the Chain-of-Survival of Children with Congenital Heart Disease.

Despite significant strides made in childhood survival during the last 75 years, India bears the largest burden of congenital heart disease (CHD) in the world. The care of a child with CHD requires multidisciplinary collaboration and development of distinct training opportunities in developing countries to ensure outcomes similar to those achieved in high-income countries. We present a commentary on the current state of pediatric cardiac critical care in India and propose pathways to fulfil the unmet needs of Indian children.

Structure-property modeling of physicochemical properties of fractal trigonal triphenylenoids by means of novel degree-based topological indices.

Trigonal triphenylenoids (TTPs) are a fascinating class of organic molecules with unique structural and electronic properties. Their diverse applications, ranging from organic electronics to nonlinear optics, have spurred significant research interest in understanding their physicochemical behavior. Topological indices, mathematical descriptors derived from the molecular graph, offer valuable insights into the structural complexity and potential properties of TTPs.

Race and Ethnicity and Exclusive Breastfeeding Success.

Breast milk is the ideal food for infants. However, at 6 months of age, <25% of infants in the United States are exclusively breastfed. While racial disparities in breastfeeding have been documented, questions remain about the contributions of paternal race and ethnicity to breastfeeding.

A fluorescent paramagnetic Mn metal-organic framework based on semi-rigid pyrene tetra-carboxylic acid: sensing of solvent polarity and explosive nitroaromatics.

An Mn metal-organic framework (Mn-MOF), Mn-L, based on a pyrene-tetraacid linker (H4 L), displays a respectable fluorescence quantum yield of 8.3% in spite of the presence of the paramagnetic metal ions, due presumably to fixation of the metal ions in geometries that do not allow complete energy/charge-transfer quenching. Remarkably, the porous Mn-L MOF with ∼25% solvent-accessible volume exhibits a heretofore unprecedented solvent-dependent fluorescence emission maximum, permitting its use as a probe of solvent polarity; the emission maxima in different solvents correlate excellently with Reichardt's solvent polarity parameter (E T (N)).

Single crystal-to-single crystal site-selective postsynthetic metal exchange in a Zn-MOF based on semi-rigid tricarboxylic acid and access to bimetallic MOFs.

The metal ions in a neutral Zn-MOF constructed from tritopic triacid H3 L with inherent concave features, rigid core, and peripheral flexibility are found to exist in two distinct SBUs, that is, 0D and 1D. This has allowed site-selective postsynthetic metal exchange (PSME) to be investigated and reactivities of the metal ions in two different environments in coordination polymers to be contrasted for the first time. Site-selective transmetalation of Zn ions in the discrete environment is shown to occur in a single crystal-to-single crystal (SCSC) fashion, with metal ions such as Fe(3+) , Ru(3+) , Cu(2+) , Co(2+) , etc.

Mobility in the structure of E.coli recQ helicase upon substrate binding as seen from molecular dynamics simulations.

RecQ helicases feature multiple domains in their structure, of which the helicase domain, the RecQ-Ct domain and the HRDC domains are well conserved among the SF2 helicases. The helicase domain and the RecQ-Ct domain constitute the catalytic core of the enzyme. The domain interfaces are the DNA binding sites which display significant conformational changes in our molecular dynamics simulation studies.

Redefining orthodontic space closure: sequential repetitive loading of the periodontal ligament--a clinical study.

Aims: To assess the rate of tooth movement, anchorage loss, root resorption, and alkaline phosphatase (ALP) activity in the gingival crevicular fluid (GCF) as a marker for bone remodeling during orthodontic space closure using two different mechanisms.

Methods: Space closure was completed in 20 patients with extraction of all 4 premolars. Lateral cephalograms and radio-visiographs taken before (T1) and after (T2) space closure were assessed for anchorage loss and root resorption.

Soft-tissue cephalometric norms in a South Indian ethnic population.

Introduction: An esthetically pleasing smile is a key determinant of successful orthodontic treatment and patient satisfaction. The great variance in soft-tissue drape of the human face complicates accurate assessment of the soft-tissue profile. Variability is also characteristic of different faces and facial types, and normative data based on 1 population group do not represent all.