Publications by authors named "Goux C"

Surgical skin preparation is performed according to peri-operative antisepsis protocols. These protocols are based on clinical practice recommendations and may vary from institution to institution. The objective of the survey, conducted among 481 surgeons and 98 scrub nurses of five specialties (cardiac, gastrointestinal, obstetrics and gynecology, orthopedics, and urology) in France was to take stock of practices to identify the protocols used for surgical skin preparation, such as measures relating to pre-operative showering, hair removal, or antisepsis of the operating area.

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Private nurses play a central role in the monitoring and treatment of wounds, particularly through their intervention in patients' homes. They play an essential role in detecting and reporting delayed healing. In order to decompartmentalize and make efficient the organization of this care, the Regional Union of Nursing Professionals of Corsica has proposed the creation of a regional coordination and expertise support system within the framework of Article 51.

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Objective: To report the nature, diagnosis and therapeutic strategy of infectious emergencies in urology.

Material And Methods: Bibliographic research from Pubmed, Embase, and Google scholar in July 2021. A synthesis of the guidelines of national infectious diseases societies.

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Background: Urinary tract infections (UTIs) are common and diverse. Even when not severe, UTIs regularly lead to hospitalization, but their hospital burden remains unknown. This study aimed to estimate the national incidence of hospitalized UTIs in France.

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Introduction: No recent national guidelines exist regarding the management of urinary tract infections (UTIs) in the presence of ureteral stent. This situation could lead to discrepancies in clinical management and less opportunity for a favorable patient's outcome.

Methods: All available data published on Medline® between 1998 and 2018 were systematically searched and reviewed.

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Purpose: Pathophysiology and risk factors for Ureteral Stent-Associated Urinary Tract Infection (USAUTI) have been poorly investigated. This situation results in highly diverse practices regarding USAUTI prevention, diagnosis and treatment. The aim of the present study was to describe the epidemiology and risk factors for USAUTI in non-transplanted patients.

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Unlabelled: Prostate biopsy is sometimes complicated by infection which can lead to death. The risk factors remain controversial, notably the urine bacterial culture carried out before a prostate biopsy. The increase in resistance induces an increase in the number of complications and the need to define new antibiotic prophylaxis strategies.

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Article Synopsis
  • This study focuses on identifying non-coding genetic alterations in bladder cancer, which have been less explored compared to changes in protein-coding genes and pathways linked to cancer development.
  • Researchers found recurrent non-coding mutations near specific genes in 62.1% of bladder tumors analyzed, indicating a potential signature of genomic instability unique to this cancer type.
  • The study suggests this mutation pattern is more common in females and correlates with higher tumor mutational burden, although it does not appear to affect patient outcomes.
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This study evaluated the prognostic value of a panel of 29 oncogenes derived from the analysis of The Cancer Genome Atlas (TCGA data) or from the recent literature on bladder tumors on a well-characterized series of muscle-invasive bladder cancer (MIBC) and non-MIBC (NMIBC) samples and tried to identify molecular prognostic markers. Mutations of HRAS, FGFR3, PIK3CA and TERT were found in 2.9%, 27.

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Promoter mutations of pleckstrin homology domain-containing S1 () are frequent in several cancer types. To evaluate the DNA mutations, the mRNA expression and prognostic value of was evaluated in bladder cancer. We investigated DNA mutations and mRNA expression of in a first series of 154 bladder tumors [71 non-muscle-invasive bladder cancer (NMIBC) and 83 muscle-invasive bladder cancers (MIBC)] from patients who underwent transurethral bladder resection or radical cystectomy between 2001 and 2006, and 20 normal bladder samples.

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Numerous pangenomic studies identified protein-coding genes and signaling pathways involved in bladder carcinogenesis. However, noncoding somatic alterations remain unexplored. A recent study revealed a mutational hotspot in intron 6 of gene in 2.

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Immunotherapy for bladder cancer has given promising results. Here we aimed to evaluate the possible involvement and prognostic value of 33 genes involved in the immune response during bladder carcinogenesis. Expression levels were assessed by quantitative real-time RT-PCR in normal and tumor human bladder samples.

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Objectives: Immunotherapy for bladder cancer seems to have promising results. Here, we evaluated the association between messenger RNA (mRNA) and protein levels and possible prognostic value of the programmed cell death 1/programmed cell death ligand 1 (PD-1/PD-L1) and cytotoxic T-lymphocyte-associated protein 4 (CTLA4) immune checkpoint pathways during bladder carcinogenesis.

Methods And Materials: Tumor samples were obtained from 155 patients (84 with muscle-invasive bladder cancer [MIBC], and 71 non-muscle-invasive bladder cancer [NMIBC]) and normal bladder tissue from 15 patients.

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Bladder cancer is the sixth cause of cancer mortality in France and prognosis of muscle-invasive tumors remains poor due to lack of effective treatments. Recent advances in molecular biology applied to tumors and results of recent genome-wide studies have brought a important impact on the understanding of bladder carcinogenesis. Main molecular alterations concern FGFR3, TP53 and HER2, and it is now possible to distinguish three subgroups of tumors according to molecular profile.

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Introduction: Upper tract urinary carcinoma (UTUC) pT3 tumors are a heterogeneous entity including tumors invading the renal parenchyma, tumors with peripelvic fat invasion or peri-ureteral fat invasion. The aim of this study was to evaluate the prognostic significance of these three different groups of pT3 tumors.

Patients And Methods: Between 1998 and 2012, 205 patients with UTUC were operated in two centers, including 52 patients with pT3 tumor stage.

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Article Synopsis
  • The study examined the occurrence and characteristics of prostate cancer (PCa) found incidentally in patients who underwent radical cystoprostatectomy (RCP) for bladder cancer, analyzing data from 4,299 male patients from 1996 to 2012.
  • Among the patients, 21.7% were found to have PCa, with the majority being at an early stage (90.1% organ-confined).
  • During follow-up, only 1.9% experienced a recurrence of PCa, and no patients died from it, highlighting a low risk associated with incidental PCa diagnosis in this context.
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Objectives: The aim of this study was to evaluate the prognostic significance of the ureteral location of the upper tract urinary carcinoma (UTUC).

Patients And Methods: Between January 1998 and December 2007, 161 patients with UTUC were operated in our center. Tumors were located on renal pelvis in 51% of cases, on the ureter in 34% of cases and in both locations in 15% of cases.

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