Publications by authors named "Goutham Belagula Manjunath"
Article Synopsis
- A clinical isolate of strain JH-1 carries genes for cytolethal distending toxin (CDT) on a conjugative plasmid, but a mutant without CDT still shows invasiveness and diarrhea-causing ability.
- Whole genome sequencing revealed two distinct type III secretion systems (T3SS) in strain JH-1, with one located on the chromosome and the other on a mega-plasmid, indicating a unique genetic structure that contributes to its virulence.
- The plasmid's T3SS is functional and can transfer between strains, suggesting a mechanism for sharing virulence traits among pathogenic bacteria, enhancing our understanding of their disease-causing abilities.
New Delhi metallo-β-lactamase-1 (NDM-1) is the major contributor to the emergence of carbapenem resistance in Gram-negative pathogens (GNPs) and has caused many clinically available β-lactam antibiotics to become obsolete. A clinically approved inhibitor of metallo-β-lactamase (MBL) that could restore the activity of carbapenems against resistant GNPs has not yet been found, making NDM-1 a serious threat to human health. Here, we have rationally developed an inhibitor for the NDM-1 enzyme, which has the ability to penetrate the outer membrane of GNPs and inactivate the enzyme by depleting the metal ion (Zn) from the active site.
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