Publications by authors named "Gouriet F"
Background: Transcatheter aortic valve replacement-related infective endocarditis (TAVR-IE) is associated with a poor prognosis. TAVR-IE diagnosis is challenging, and benefits of the most recent classifications (ESC-2015, ISCVID-2023 and ESC-2023) have not been compared with the conventional Duke criteria on this population.
Objectives: The primary objective was to compare the diagnostic value of the Duke, ESC-2015, ISCVID-2023, and ESC-2023 criteria for the diagnosis of TAVR-IE.
Background: Aortic valve infective endocarditis may be complicated by high-degree atrioventricular block in up to 10-20% of cases.
Aim: To assess high-degree atrioventricular block occurrence, contributing factors, prognosis and evolution in patients referred for aortic infective endocarditis.
Methods: Two hundred and five patients referred for aortic valve infective endocarditis between January 2018 and March 2021 were included in this study.
Article Synopsis
- * Researchers compared two groups of patients—one from the pandemic period and one from the previous year—looking at their clinical outcomes, treatments, and overall management.
- * The findings indicated that the pandemic did not significantly affect the treatment and mortality rates of IE patients, though there was an increase in intravenous drug-related cases, highlighting a potential psychosocial impact of the pandemic.
Preliminary landscape of Saccharibacteria in the human microbiome.
Front Cell Infect Microbiol
August 2023
Article Synopsis
- * Research methods included both prospective and retrospective screening techniques, such as PCR, real-time PCR, and scanning electron microscopy, to analyze the prevalence of TM7 in different human samples.
- * Findings revealed that TM7 were most common in oral samples, with lower prevalence in other bodily fluids, and even found in some infectious samples, highlighting their status as human commensals and suggesting the need for more research on their potential role in disease contexts.
Multimodality imaging in marantic endocarditis associated with cancer: a multicentric cohort study.
Eur Heart J Cardiovasc Imaging
November 2023
Aims: We aimed to assess the role of multimodality imaging (MMI) in the diagnosis of marantic endocarditis (ME) associated with cancers and to describe the clinical characteristics, management, and outcome of these patients.
Methods And Results: In a retrospective multicentric study including four tertiary centres for the treatment of endocarditis in France and Belgium, patients with a diagnosis of ME were included. Demographic, MMI [echocardiography, computed tomography (CT), and 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT)], and management data were collected.
Background: The influence of different bicuspid aortic valve (BAV) morphology in the clinical course of infective endocarditis (IE) has not yet been investigated. This study aimed to describe the clinical and echocardiographic features of IE in patients with BAV (BAVIE) according to valve morphology.
Methods: Patients with definite BAVIE prospectively enrolled in 4 high-volume referral centers from 2000 to 2019 were evaluated and divided into 2 groups according to the echocardiographic definition of fused BAV morphology: right-left coronary (RL type) and right noncoronary or left noncoronary (non-RL type) cusp fusion.
Influence of the healthcare pathway on the outcome of patients with infective endocarditis.
Eur Heart J Acute Cardiovasc Care
September 2022
Article Synopsis
- The study investigates the prognosis of patients with infective endocarditis (IE) based on their healthcare pathway and the application of ESC guidelines in their treatment.
- Conducted in 22 hospitals in South-East France, the research involved 342 patients divided into three groups: those treated entirely in referral centers, those initially treated in non-referral centers then referred, and those entirely treated in non-referral centers.
- Results showed a one-year mortality rate of 26%, with significantly higher mortality (37%) for patients treated solely in non-referral centers compared to those in referral and transferred centers, indicating that healthcare pathway significantly impacts patient outcomes.*
Whipple's disease (WD) is a chronic multisystemic infection caused by . If this bacterium presents an intracellular localization, associated with rare diseases and without pathognomonic signs, it is often subject to a misunderstanding of its physiopathology, often a misdiagnosis or simply an oversight. Here, we report the case of a patient treated for presumed rheumatoid arthritis.
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- Blood is typically sterile tissue, but in this study, three bacterial strains were isolated from individuals suffering from bacteremia for further investigation.* -
- The strains included two Gram-positive non-spore-forming rod-shaped bacteria (Marseille-P7157T and Marseille-Q2854T) and one Gram-negative motile rod-shaped bacterium (Marseille-P8049T), with distinct major fatty acids identified.* -
- Genomic analysis revealed significant sequence similarities with known species, leading to the classification of these newly isolated strains as different species: Acinetobacter ihumii sp. nov., Microbacterium ihumii sp. nov., and Gulosibacter massiliensis sp. nov.*
Background: In native mitral valve infective endocarditis (NMIE), the respective values of mitral valve repair (MVRep) and replacement (MVR) are still debated.
Aim: To compare MVRep and MVR in a large prospective matched cohort.
Methods: Between 2010 and 2017, all consecutive patients operated on for NMIE in our centre were included prospectively.
The aetiology of appendicular abscess is predominantly microbial with aerobic and anaerobic bacteria from gut flora. In this study, by using specific laboratory tools, we co-detected Methanobrevibacter oralis and Methanobrevibacter smithii among a mixture of enterobacteria including Escherichia coli, Enterococcus faecium and Enterococcus avium in four unrelated cases of postoperative appendiceal abscesses. These unprecedented observations raise a question on the role of methanogens in peri-appendicular abscesses, supporting antibiotics as an alternative therapeutic option for appendicitis, including antibiotics active against methanogens such as metronidazole or fusidic acid.
View Article and Find Full Text PDFPain sensitization leading to polyalgia can be observed during infectious diseases. The blood pressure cuff-evoked pain threshold (BPCEPT) has been used in previous studies as a screening tool for fibromyalgia.We aimed to use the BPCEPT as a screening test for detecting pain sensitization in patients suffering from infectious diseases.
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- Untreated tonsillar phlegmon can be life-threatening and is often caused by various pathogens.
- Researchers used specific lab tools to identify certain microbes involved in this condition.
- The findings challenge current understandings of methanogens' roles in phlegmon and suggest a need to reassess treatment approaches for mixed infections.
Background: Infective endocarditis (IE) is associated with a high mortality rate, related in part to neurological complications. Studies suggest that valvular surgery should be performed early when indicated, but is often delayed by the presence of neurological complications.
Aim: To assess the effect of delaying surgery in patients with IE and neurological complications and to identify factors predictive of death.
Article Synopsis
- F-FDG PET/CT is now included in the ESC 2015 guidelines for diagnosing infective endocarditis, but its effectiveness in native valve endocarditis (NVE) is not fully understood.
- A study involving 75 patients identified that while F-FDG PET/CT had low sensitivity (17.5%) for diagnosing NVE, it maintained high specificity (100%) and was effective for detecting embolic events.
- The research also revealed a new diagnostic feature of diffuse splenic uptake seen in over half of the patients with NVE, suggesting its potential utility in clinical practice.
The objective of this study is to determine the acquisition of multidrug-resistant (MDR) bacteria and antibiotic resistance-encoding genes by French Hajj pilgrims and associated risk factors. Pilgrims traveling during the 2017 and 2018 Hajj were recruited. All pilgrims underwent two successive systematic nasopharyngeal and rectal swabs, pre- and post-Hajj.
View Article and Find Full Text PDFBackground: Acquisition of multidrug resistant bacteria (MDR) and colistin resistance genes by international travellers has been demonstrated. Studies conducted in medical students during internships abroad are scant.
Methods: Nasopharyngeal, rectal, and vaginal swabs samples were collected from 382 French medical students before and after travel to investigate the acquisition of MDR bacteria.
We developed a novel culture medium, referred to FastFung medium as suitable for the culture of clinical fungi, including fastidious ones, for both research and diagnostic studies. It is based on Schædler agar supplemented with many essential components for the growth of fastidious fungi. It also contains selective antibacterial agents for the inhibition of contaminant bacteria growth.
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- Fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) is essential for managing infective endocarditis (IE) and detecting cancer.
- Between 2009 and 2018, a study of 750 IE patients showed that 451 underwent PET/CT, leading to incidental cancer diagnoses in 36 patients.
- The highest rates of detected cancers included colorectal, lung, and various others, suggesting PET/CT is highly sensitive and may be useful for cancer screening in IE patients.
International travel has increased dramatically over the past 50 years, and travel destinations have diversified. Although physicians are more familiar with the panel of aetiological agents responsible for illnesses of returning travellers, thanks to regular epidemiological studies, the spectrum of pathogens potentially encountered in various travel destinations is nevertheless increasing. In addition, the wide array of approaches currently available and addressed in this paper could render the procedures for microbiological analyses increasingly complex.
View Article and Find Full Text PDFBackground: Most cases of left-sided native valve infective endocarditis (IE) involve a single valve and little is known concerning IE that simultaneously affects the aortic and mitral valves.
Methods: We aimed to determine the characteristics, identify the prognostic factors, and define the effect of early surgery for patients with left-sided native bivalvular IE. This analysis included 1340 consecutive patients who presented with definite acute left-sided native valve IE in a 2-centre cohort study.
Article Synopsis
- Infectious endocarditis (IE) is a serious heart disease associated with high mortality, often due to thrombo-embolic events.
- Current treatment involves surgery and antibiotics, but complications persist due to limited understanding of cell organization in vegetations caused by different bacteria.
- The study utilized scanning electron microscopy and energy-dispersive X-ray spectroscopy to analyze infected heart valve tissue, revealing differences in cell organization and chemical features that could help tailor therapies based on the specific infection.
Article Synopsis
- A study was conducted to explore the presence of methanogens, specifically Methanobrevibacter smithii, in the blood of febrile patients using advanced laboratory techniques like PCR and metagenomics.
- Out of 7,716 blood samples tested, methanogens were detected in a small fraction of culture-positive anaerobic bottles, revealing a connection with other bacterial species in several patients.
- The findings suggest that M. smithii can lead to infections such as archaemia and endocarditis in patients who also have bacterial infections, highlighting the need for further investigation into methanogens' role in human diseases.