Publications by authors named "Goulabchand R"
Importance: The Oral Rheumatoid Arthritis Trial Surveillance demonstrated an increased cancer risk among patients with rheumatoid arthritis (RA) taking tofacitinib compared with those taking tumor necrosis factor inhibitors (TNFis). Although international cohort studies have compared cancer outcomes between TNFis, non-TNFi drugs, and Janus kinase inhibitor (JAKis), their generalizability to US patients with RA is limited.
Objective: To assess the comparative safety of TNFis, non-TNFi drugs, and JAKis among US patients with RA (ie, the cancer risk associated with the use of these drugs among these patients).
Article Synopsis
- - The study investigated whether frailty status increases the risk of readmission in patients with rheumatoid arthritis (RA) using data from the 2018 Nationwide Readmissions Database.
- - Results showed that frail patients (48.1% of the sample) had significantly higher readmission rates (56.60% vs 30.61%), higher inpatient mortality (3.36% vs 0.39%), and longer hospital stays compared to non-frail patients.
- - On further analysis, frailty was linked to a 9% increased risk of readmission, highlighting the importance of identifying frail RA patients for better discharge planning and care.
Objective: The objective of this study was to evaluate the association between frailty status and risk of readmissions, inpatient death, and cost of admission among patients with systemic lupus erythematosus (SLE).
Methods: We conducted a retrospective cohort study using the National Readmissions Database. Using International Statistical Classification of Diseases, Tenth Revision codes, we identified individuals >18 years of age who had a primary or secondary diagnosis of SLE and were hospitalized between January and June 2018.
Article Synopsis
- - The study focused on examining the relationship between primary Sjögren's syndrome (pSS) and cancer, specifically analyzing the clinical, pathological, and immunological aspects of pSS patients who also had cancer, compared to those without cancer.
- - Out of 165 pSS patients, 55 had cancers, primarily solid neoplasms, with breast and lung cancers being the most common; significantly, many cancers were diagnosed close to or shortly after the pSS diagnosis.
- - Findings suggest that there may be a connection between breast cancers and pSS, implying that the immune system's behavior in pSS patients could play a role in cancer development or control.
Article Synopsis
- - The study evaluated malnutrition prevalence in systemic sclerosis (SSc) patients at a referral center from 1985 to 2019, finding that 59.2% were malnourished and 25% had severe malnutrition.
- - Malnutrition correlated with disease features, specifically cardiac involvement and limited mouth opening (interincisal distance <35 mm), indicating potential warning signs.
- - The findings suggest that addressing malnutrition could be crucial for improving health outcomes in SSc patients, given its high prevalence and associations with serious disease symptoms.
Article Synopsis
- The study aimed to identify key coding genes linked to biomarkers and pathways in giant cell arteritis (GCA) by analyzing temporal arteries from GCA patients and controls.
- Researchers used spatial profiling and transcriptome analysis on temporal artery biopsy samples, discovering significant gene expression differences across various layers of the arteries.
- The results highlighted that many genes related to immune processes and vascular remodeling were upregulated in GCA arteries, suggesting new potential treatment targets for immunotherapies.
Objectives: CTLA4 deficiency (CTLA4d) is a disease with multisystem autoimmune features, including neurologic manifestations. We aimed to describe neurologic involvement in these patients.
Methods: We performed a cross-sectional observational study using the French Reference Centre for Primary Immunodeficiencies (CEREDIH) registry plus a surveillance in national society networks.
Introduction: Internal medicine departments manage patients referred by emergency departments or private practitioners. Considering the overcrowding of emergency departments and lack of beds for inpatients, this specialty must be part of an "ambulatory shift", particularly by strengthening the links between community and hospital medicine. Our objective was to evaluate a new care pathway in internal medicine at Nîmes university hospital.
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- Subcutaneous tissue involvement in idiopathic inflammatory myopathies (IIM) is not well understood, prompting a systematic review of related conditions like panniculitis and lipodystrophy in both juveniles and adults.
- The findings indicate that panniculitis is more common in adults, responds well to steroid treatment, and often aligns with the progression of myositis; in contrast, lipodystrophy is mainly found in juveniles and linked to dermatomyositis.
- The study concludes that lipodystrophy's relationship with myositis diagnosis and potential poor disease control suggests a need for more extensive research to identify risk factors and therapeutic targets in these patients.
We aimed to assess the factors associated with mortality in patients treated with tocilizumab for a SARS-CoV-2 pneumonia due to the delta or omicron variants of concern (VOC) and detect an effect of tocilizumab on mortality. We conducted a prospective cohort study in a tertiary hospital from 1 August 2021 to 31 March 2022 including patients with severe COVID-19, treated with tocilizumab. Factors associated with mortality were assessed in a Cox model; then, the 60-day mortality rates of COVID-19 patients treated with standard of care (SoC) +/- tocilizumab were compared after 1:1 propensity score matching.
View Article and Find Full Text PDFObjective: Giant cell arteritis (GCA) has a relapsing-remitting course and is associated with a high burden of comorbidities, leading to repeated hospitalizations. This study was undertaken to investigate the burden, risk factors, causes, and outcomes of hospitalization and readmission in GCA patients in a US national cohort.
Methods: Using the 2017 US National Readmission Database, we identified adults ≥50 years of age hospitalized with GCA between January and June 2017, with at least 6 months of follow-up.
Introduction: Infections are responsible for a part of the overall mortality in primary Sjögren's syndrome patients (pSS). Our retrospective monocentric study aimed at describing infections reported in a population of pSS hospitalized patients, along with the characteristics of their disease.
Methods: Patients with SS have been randomly selected from our hospital database claim, between 2009 and 2018.
Background: Primary Sjögren's syndrome (pSS) is an autoimmune disease with increased risk of infections. Here, we assessed whether pSS patients were at higher risk of hospitalization for community and opportunistic infections.
Methods: We selected newly hospitalized pSS patients between 2011 and 2018, through a nationwide population-based retrospective study using the French Health insurance database.
Article Synopsis
- Researchers tested whether anakinra, a drug for blocking interleukin-1 receptors, could help moderate COVID-19 patients requiring oxygen treatment.
- In a trial with 71 enrolled patients, those receiving anakinra had lower treatment success and higher mortality at 28 days compared to those receiving standard care.
- The study concluded that anakinra was not effective and even proved to be worse than standard care for treating moderate COVID-19 pneumonia.
Primary Sjögren's syndrome (pSS) is an autoimmune disease with frequent neurological involvement. Memory complaints are common, but their precise patterns remain unclear. We wanted to characterize patterns of neurocognitive profiles in pSS patients with cognitive complaints.
View Article and Find Full Text PDFObjectives: Giant cell arteritis (GCA) is associated with severe outcomes such as infections and cardiovascular diseases. We describe here the impact of GCA patients’ characteristics and treatment exposure on the occurrence of severe outcomes. Methods: Data were collected retrospectively from real-world GCA patients with a minimum of six-months follow-up.
View Article and Find Full Text PDFObjectives: Sjögren's syndrome (SS) and ANCA-associated vasculitis (AAV) have distinct clinical presentation and evolution, with paucity of reports on overlap syndrome. We aimed to better characterize this entity.
Methods: We report four additional cases from the Montpellier university hospital.
Primary Sjögren’s syndrome (pSS) can be associated with neurological and cognitive involvement, negatively affecting patients’ quality of life. The aim of this study was to assess whether pSS patients are at higher risk of hospitalization for neurological diseases. Through a nationwide retrospective study using the French Health insurance database (based on International Classification for Disease codes, ICD-10), we selected patients hospitalized with new-onset pSS between 2011 and 2018.
View Article and Find Full Text PDFBackground: Inflammation of unknown origin (IUO) is a challenging situation in internal medicine.
Objectives: To describe the final diagnoses in IUO and assess the helpfulness of F-fluorodesoxyglucose positron emission tomography with computerized tomography ( F-FDG-PET/CT) in the diagnosis strategy.
Results: A total of 317 IUO patients with F-FDG-PET/CT were enrolled.
Objectives: To describe the characteristics, treatment and outcome of patients with immune thrombocytopenia with clinical significance (ITPCS) associated with SLE.
Methods: This retrospective multicentre study included SLE patients who experienced ≥1 ITPCS (defined as ITP with attributable bleeding disorders and/or a platelet count <30×109/l). Other causes of secondary thrombocytopenia were excluded.