Publications by authors named "Gou Haiyan"
Background: Delayed sleep-wake phase disorder (DSWPD) is common and easily misdiagnosed in young people, and to date, there is no evidence-based treatment.
Purpose: A nonblinded randomized controlled study evaluated the effect of agomelatine therapy (AT) and cognitive behavior therapy (CBT) on DSWPD in young adults.
Methods: Sixty adolescents and young adults (range = 19-24 years, mean = 22 years, 52% female) diagnosed with DSWPD were randomized to receive 4 weeks of agomelatine therapy with or without cognitive behavior therapy.
WGCNA combined with GSVA to explore biomarkers of refractory neocortical epilepsy.
IBRO Neurosci Rep
December 2022
About two-thirds of epilepsy patients relapse within five years after surgery. It is significant to note that the limitations of current treatments stem from a lack of understanding of molecular mechanisms. In this study, Weighted Gene Co-expression Network Analysis (WGCNA) and Gene set variation analysis (GSVA) methods were used to analyze the total RNA data from 20 surgical removal samples (epileptogenic zone and irritative zone, EZ and IZ) of 10 Chinese patients with refractory neocortical epilepsy downloaded from the original microarray dataset (GSE31718) of the National Center for Biological Information -Gene Expression Omnibus database (NCBI-GEO).
View Article and Find Full Text PDFBackground: To determine treatment effects on the incidence of post-stroke epilepsy (PSE) using different doses of statin, a prospective hospital-based cohort study was designed to explore whether a double-dose statin treatment can better prevent the occurrence of PSE.
Methods: A total of 1152 patients with newly diagnosed ischemic stroke admitted to our hospital from March to August 2017 were selected, 1033 of whom were followed-up. Patients were divided into two treatment groups:(1) standard-dose (20 mg atorvastatin or 10 mg rosuvastatin,daily oral; 788 patients); and (2) double-dose (40 mg atorvastatin or 20 mg rosuvastatin, daily oral; 245 patients).
Article Synopsis
- * The research found that 627 circRNAs were up-regulated and 892 down-regulated in mice with seizures, highlighting a significant decrease in circHivep2 levels in the hippocampus during epileptic activity.
- * Overexpression of circHivep2 reduced microglial activation and inflammation in the brain, suggesting that it could be a potential therapeutic target for epilepsy by modulating the miR-181a-5p/SOCS2 signaling pathway.
Objectives: Decreased cerebrospinal fluid (CSF) orexin levels are one of the diagnostic and classification criteria for narcolepsy. Because of the difficulty in obtaining CSF, its clinical application is limited. Here, we aimed to confirm the significance of determining plasma orexin levels in the diagnosis and treatment of narcolepsy by comparing the differences in these levels between narcolepsy patients and healthy controls and analyzing related factors.
View Article and Find Full Text PDFStudy of Seizure-Manifested Hartnup Disorder Case Induced By Novel Mutations in .
Open Life Sci
January 2018
Article Synopsis
- The study aims to explore a gene variation in a female patient with Hartnup disorder who only experienced seizures.
- Researchers analyzed DNA samples from the patient and her parents, identifying mutations in the gene that are missense and inherited.
- The findings reveal two new mutations linked to the patient's neurological symptoms, although she does not show the usual skin issues typically associated with the disorder.