Publications by authors named "Gotfredsen Klaus"

Background: Primary Sjögren's syndrome (pSS) is a chronic systemic autoimmune disease characterized by hyposalivation. Currently, there is limited evidence for the prognosis of dental implant treatment in Sjögren's syndrome.

Aim/hypothesis: We hypothesized comparable clinical outcomes of implant-supported restorations in pSS-patients and control subjects, and improvement in oral health-related quality of life 5 years after restoration.

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Objectives: The primary aim was to investigate survival rate of zirconia versus metal abutments, and the secondary aim was clinical outcomes of all-ceramic versus metal-ceramic crowns on single-tooth implants.

Methods: Patients with tooth-agenesis participated to previously published prospective clinical study with 3-year follow-up were recalled after 5 years. Biological variables included survival and success rate of implants, marginal bone level, modified Plaque and Sulcus Bleeding Index and biological complications.

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Objectives: The purpose of this systematic review is to disclose the impact of autoimmune diseases and their medical treatment on dental implant survival and success.

Material And Methods: A literature search was conducted using MEDLINE (PubMed), The Cochrane Library and Embase up to December 6, 2021. Any clinical study on patients with an autoimmune disease in whom implant therapy was performed was eligible.

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Background: Different treatment options exist for replacement of an anterior tooth, and as implant-supported single crowns (ISSC) and resin-bonded fixed dental prosthesis (RBFDPs) both are widespread treatment options, it is of clinical relevance to know which treatment modality can be considered superior.

Purpose: The purpose of this comparative study was to evaluate the 3- and 5-year survival and failure rate of tooth-supported resin-bonded fixed dental prosthesis compared to implant-supported single crowns. The null hypothesis was that there was no significant difference in survival rate, occurrence of complications or patient-reported outcome between RBFDPs and ISSCs.

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Evidence-based dentistry used for decision-making and assessment of treatment includes three components: evidence from the literature, clinical expertise, and patient expectations. Patient satisfaction embraces affability, availability, and ability and can be examined using questionnaires or structured questions to the patient to evaluate patient perception of the treatment. The questions can be quantified using dichotomous, point, or visual analog scales.

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Statement Of Problem: Digital scanning has become popular and has been reported to be more comfortable for patients and equally or more accurate than conventional impression techniques. However, clinical evidence to support the advantages of digital scanning is sparse.

Purpose: The purpose of this randomized crossover study was to examine and compare the patient and provider perceptions of digital scanning and conventional impression making for implant-supported single crowns (ISSCs) provided by dental students under supervision.

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Purpose: To evaluate the marginal and internal fit of lithium disilicate and zirconia crowns using two optical coherence tomography (OCT) systems in order to estimate inter-system variations.

Materials And Methods: Ten lithium disilicate and 10 cubic stabilized zirconia crowns were placed on prepared artificial teeth without cement. Marginal discrepancy and internal cement gap of the crowns were assessed on images obtained using a swept source OCT (SS-OCT) and a spectral domain OCT (SD-OCT).

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Objectives: Oral rehabilitation can be a challenge in patients on high-dose antiresorptive medication (HDAR), especially if the alveolar anatomy has changed due to previous medication-related osteonecrosis of the jaw (MRONJ) resection. In healthy patients, dental implant treatment has found wide acceptance in prosthetic rehabilitation as it increases the patient's oral health-related quality of life. However, it is considered contraindicated in patients on HDAR due to the risk of MRONJ, although a recent feasibility study indicates that implant treatment may indeed be an option in these patients.

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Objective: To compare 5-year biological, technical, aesthetic, and patient-reported outcomes of single-tooth implant-supported all-ceramic versus metal-ceramic restorations.

Materials And Methods: Thirty patients with 63 premolar agenesis participated in the 5-year follow-up. The prosthetic treatment on single-tooth implants was randomly assigned to all-ceramic crowns on zirconia abutments (AC = 31) or metal-ceramic crowns on metal abutments (MC = 32).

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Purpose: Implant placement in patients with cancer receiving high-dose antiresorptive medication (HDAR) is considered contraindicated. This prospective, feasibility study tested the hypothesis that dental implants can be placed in such patients by applying a staged implant placement protocol with submerged healing.

Methods: Three groups of patients on HDAR were included as follows: group 1: patients who underwent tooth extraction, without the development of medication-related osteonecrosis of the jaws (MRONJ); group 2: patients with surgically treated MRONJ who had demonstrated clinical healing for at least 3 months; group 3: patients with established MRONJ who was planned for surgical resection and simultaneous implant placement.

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Aim: The aim of this systematic review was to answer the following focused question: "In partially edentulous patients with periodontitis, are removable dental prostheses (RDPs) more efficacious than no prosthetic treatment, treatment to a shortened dental arch (SDA), or tooth-supported fixed dental prostheses (FDPs)?"

Materials And Methods: A systematic literature search was performed electronically for the period 1966-2020. Two authors independently assessed the studies for eligibility according to the PRISMA guidelines. Risk assessment was performed using RoB 2.

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Unlabelled: Protocols for implant dentistry, most frequently include periods until healing of the extraction sockets and osseointegration of the implant. Deductional thinking imply that patients would prefer if treatment time in implant dentistry were reduced.

Aim: What is the patient perception of immediate or early implant placement or loading in comparison with traditional, delayed placement, and/or loading assessed by patient-reported outcome measures, as evidenced in randomized controlled clinical trials or prospective controlled studies?

Material And Methods: A systematic review was performed following the PRISMA guidelines with a literature search up to June 30.

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Objectives: This publication reports on the EAO workshop group 1 summaries, discussions and consensus statements based on four systematic reviews evaluating the impact of timing of dental implant placement and loading.

Materials And Methods: The first of the systematic reviews was on the influence of the timing of implant placement and loading in the biological outcomes of implant-supported fixed partial dentures. The second systematic review evaluated the influence of the timing of implant placement and loading on the aesthetic outcomes in single-tooth implants.

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Background: This cross-sectional study assessed the potential of colored periodontal probes (CPP) to classify gingival phenotype in terms of gingival thickness (GT).

Methods: Buccal GT in three anterior teeth in each of 50 patients was measured by transgingival sounding and classified by three different methods by eight examiners. Specifically, the diagnostic potential of visual judgment and transparency of a standard periodontal probe (SPP) to discriminate thin and thick gingiva, and of CPP to discriminate thin, medium, thick, or very thick gingiva was assessed.

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Objective: Medication-related osteonecrosis of the jaw (MRONJ) is a serious adverse reaction to high-dose antiresorptive medication (AR) in patients with cancer. A temporary discontinuation of AR (drug holiday) has been suggested to potentially reduce the risk of MRONJ after oral surgery. However, no consensus exists.

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Objective: To compare fully guided with conventionally guided implant surgery performed by dental students in terms of deviation of actual implant position from an ideal implant position.

Materials And Methods: Twenty-five patients in need of 26 straightforward implant-supported single crowns were randomly allocated to a fully guided (FG, n = 14) or a conventionally guided (CG, n = 12) implant surgery. In the preoperative CBCTs, 3 experienced investigators placed a virtual implant in the ideal position, twice, allowing deviational analysis in the facio-lingual (coronal) and mesio-distal (sagittal) planes for 7 parameters.

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Purpose: To compare in a randomized controlled trial the 5-year clinical outcomes of (1) 3-unit fiber-reinforced resin-bonded fixed dental prostheses (RBFDPs) to 3-unit metal-ceramic RBFDPs; and (2) 3-unit fiber-reinforced RBFDPs to 2-unit cantilevered metal-ceramic RBFDPs.

Materials And Methods: A consecutive sample of 50 young adult patients with tooth agenesis or trauma in the anterior region was included. The recruitment period was from 2005 to 2009, during which a total of 62 RBFDPs were inserted.

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A temporary discontinuation (drug holiday) of high-dose antiresorptive (AR) agents has been proposed to reduce the risk of medication-related osteonecrosis of the jaw (MRONJ). The aim of this systematic review was to answer the question: Is high-dose AR drug holiday, at the time of tooth extraction or dentoalveolar surgery, necessary to prevent the development of MRONJ in patients with cancer? This protocol was registered in the PROSPERO database. Medline, Embase, and the Cochrane Central Register of Controlled Trials (CENTRAL) were searched for relevant studies up to and including April 2019.

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This study aims to investigate the responsiveness of the Danish treatment pathway for head-and-neck-cancer (HNC) patients receiving oral rehabilitation. Eighteen HNC-patients who had received oral rehabilitation as well as five medical and four oral health care professionals involved in the treatment of HNC-patients filled in a questionnaire on responsiveness. The responsiveness was further described in individual interviews in the HNC-patients and focus group interviews in the health care professionals.

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Objectives: To evaluate the biological and aesthetic outcome of connective tissue grafting around single-tooth implant replacements in the anterior maxilla after five years.

Materials And Methods: Nineteen patients (mean age: 22) received 33 implants in combination with bone grafts. After healing, 10 implant sites received facial connective tissue grafts harvested from the palate (test group).

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Objectives: To compare the patient-reported effect of treatment with implant-supported fixed prosthesis (ISFP) and fixed dental prosthesis (FDP) in patients with a small number of tooth losses to replace.

Methods: From a population of 155 patients receiving either ISFP or FDP, 68 patients were matched in pairs based on gender, number of teeth replaced, zone of replacement, age and number of remaining teeth. The patient-reported effect was prospectively obtained by measuring change in the short-form oral health impact (OHIP-14) from before to one month after treatment.

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Statement Of Problem: The replacement of 2 adjacent missing teeth remains a clinical challenge. Among the different treatment options, the use of a single implant to support a 2-unit cantilever fixed dental prosthesis (FDP) has been proposed in situations of limited mesiodistal space, even though the evidence for its use is low.

Purpose: The purpose of this retrospective comparative case series was to evaluate hard and soft peri-implant tissues in patients with 2 adjacent missing teeth in the anterior area (incisors or canines) rehabilitated with implant-supported 2-unit cantilevers or single crowns on adjacent implants.

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Objectives: Implantoplasty, that is, the mechanical modification of the implant, including thread removal and surface smoothening, has been proposed during surgical peri-implantitis treatment. Currently, there is no information about any potential mechanical and/or biological complications after this approach. The aim of the current review was to systematically assess the literature to answer the focused question "Are there any mechanical and/or biological complications due to implantoplasty?".

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Purpose: To assess the effect of the shooting angle variation on linear and planimetric measurements of the pink and white tissues on intraoral photographs.

Methods: From intraoral three-dimensional (3D) scans of the anterior region in 10 patients, ninety-nine two-dimensional (2D) "scan pictures" each were generated with different shooting angles, each varying in 5° horizontal and vertical increments. Eleven intraoral photographs of each patient and tooth site were taken free-hand: one shot at baseline and 5 shots after 3 and 6 months at slightly varying shooting angles.

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Head and neck cancer (HNC) is diagnosed in more than 500 000 patients every year worldwide with increasing prevalence. Oral rehabilitation is often needed after HNC treatment to regain oral function, aesthetics and oral health-related quality of life (OHRQoL). The objectives were to evaluate OHRQoL, oral aesthetics and oral function after oral rehabilitation in HNC patients and compare it to that of non-HNC patients.

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