Chemical composition, mutagenicity, and cytotoxicity of urban submicron particulate matter (PM) in Agra, India.

This study, conducted in Agra, India, examined the mass concentrations, chemical compositions, and seasonal variations of submicron particles (PM). The concentrations of metals, water-soluble inorganic ions (WSIs) including anions (F, Cl, NO₃, SO₄) and cations (Ca, K, Mg, NH₄, Na), organic carbon (OC) and elemental carbon (EC) and polycyclic aromatic hydrocarbons (PAHs) in PM extract were determined using Inductively Coupled Plasma-Optical Emission Spectroscopy (ICP-OES), Ion Chromatography, Thermogravimetric Analysis and Gas Chromatography-Mass Spectrometry (GC-MS) respectively. For morphological observation of PM particles, Field Emission Scanning Electron Microscopy-Energy Dispersive X-ray spectrometry (FESEM-EDS) was used.

A Synthetic Route to Tetrahydro-1-azepino[4,3,2-]indoles via Ring-Opening Cyclization of Activated Azetidines with 4-Bromoindole: Toward a Vasopressin V2 Receptor Antagonist.

A simple one-pot, two-step strategy for the synthesis of tetrahydro-1-azepino[4,3,2-]indoles via Lewis acid-catalyzed S2-type ring opening of activated azetidines with 4-bromoindole, followed by a Pd-catalyzed intramolecular C-N cyclization reaction, with good to excellent yields is described. Utilizing this protocol, the vasopressin V2 receptor antagonist precursor has been synthesized easily. Enantioenriched tetrahydro-1-azepino[4,3,2-]indoles were obtained by starting from enantiopure azetidine.

Perioperative outcomes and platinum resistant recurrence in patients undergoing systematic, protocol-based, total parietal peritonectomy during interval cytoreductive surgery for advanced ovarian cancer: results of the TORPEDO study.

Objective: The TORPEDO (CTRI/2018/12/016789) is the single-arm, prospective, interventional study evaluating the role of a total parietal peritonectomy (TPP) in patients undergoing interval cytoreductive surgery (iCRS). In this manuscript, we report the perioperative outcomes and platinum resistant recurrence (PRR) in 218 patients enrolled in the study.

Methods: A TPP was performed in all patients undergoing iCRS irrespective of the residual disease extent.

An oxalate decarboxylase-like cupin domain containing protein is involved in imparting acid stress tolerance in Bacillus amyloliquefaciens MBNC.

We report here the structural and functional properties of an oxalate decarboxylase (OxDC)-like cupin domain-containing protein of Bacillus amyloliquefaciens MBNC and its role in imparting tolerance to acid stress conditions. Quantitative real-time PCR (qPCR) analysis revealed 32-fold and 20-fold upregulation of the target gene [(OxDC')cupin] under acetic acid stress and hydrochloric acid stress, respectively, indicating its association with the acid stress response. Bacterial cells with targeted inactivation of the (OxDC')cupin gene using the pMUTIN4 vector system showed decreased growth and survival rate in acidic pH, with drastically reduced exopolysaccharide production.

Primary Sellar Neuroblastoma Masquerading as a Pituitary Macroadenoma.

Olfactory neuroblastomas, or esthesioneuroblastomas, are rare and aggressive malignant tumors that typically arise from the olfactory neuroepithelium in the upper nasal cavity. In rare instances, they can be ectopic originating from areas outside the upper nasal cavity such as the sellar region. These tumors, also known as primary sellar neuroblastomas, may be mistaken for pituitary macroadenomas.

Mortality in Two Waves of COVID-19: A Comparative Analysis of a Tertiary Care Hospital in India.

Background COVID-19 has spread as two distinct surges of cases in many countries. Several countries have reported differences in disease severity and mortality in the two waves. Objective Compare the in-hospital mortality in the two COVID-19 waves at a tertiary care hospital in India.

Simultaneous Presentation of Secondary Adrenal Insufficiency and Primary Hypothyroidism due to Pembrolizumab: A Case Report.

Checkpoint inhibitors have gained increased traction in recent years as they have improved prognosis in various malignancies. Pembrolizumab, an anti-programmed cell death protein (PD-1) monoclonal antibody, has become a first-line chemotherapeutic agent for stage II non-small cell lung cancer since 2019. Although much more common with nivolumab, several immune-related adverse effects, particularly endocrinopathies, have been linked with pembrolizumab.

The role of chemical fractionation in risk assessment of toxic metals: a review.

The identification of highly toxic metals like Cd, Ni, Pb, Cr, Co or Cu in ambient particulate matter (PM) has garnered a lot of interest recently. Exposure to toxic metals, including carcinogenic ones, at levels above recommended limits, can significantly affect human health. Prolonged exposure to even trace amounts of toxic or essential metals can also have negative health impacts.

Factors Associated with Children's Subjective Wellbeing During COVID-19 Pandemic in Bangladesh.

The study of subjective wellbeing has received increasing interest among social science researchers and policy makers in the wake of the COVID-19 pandemic. However, there appears to be a gap in the knowledge in terms of how the children experienced the pandemic, which may be different from the experience encountered by the adults. This article fills this gap by (a) examining children's self-reported experience of the pandemic in Bangladesh and (b) identifying the socio-demographic, economic and psycho-social factors which were associated with their subjective wellbeing during the pandemic in the country.

Ring-Opening Cyclization (ROC) of Aziridines with Propargyl Alcohols: Synthesis of 3,4-Dihydro-2-1,4-oxazines.

Activated aziridines react with propargyl alcohols in the presence of Zn(OTf) as the Lewis acid catalyst following an S2-type ring-opening mechanism to furnish the corresponding amino ether derivatives. Those amino ethers further undergo intramolecular hydroamination via cyclization in the presence of Zn(OTf) as the catalyst and tetrabutylammonium triflate salt as an additive under one-pot two-step reaction conditions. However, for nonracemic examples, ring-opening and cyclization steps were conducted under two-pot conditions.

Modeling COVID-19 Transmission Dynamics: A Bibliometric Review.

A good amount of research has evolved just in three years in COVID-19 transmission, mortality, vaccination, and some socioeconomic studies. A few bibliometric reviews have already been performed in the literature, especially on the broad theme of COVID-19, without any particular area such as transmission, mortality, or vaccination. This paper fills this gap by conducting a bibliometric review on COVID-19 transmission as the first of its kind.

Ischemic stroke: a rare complication of a large multinodular goiter.

Summary: Mass effect from a goiter is a serious complication with potentially life-threatening consequences. In rare instances, a goiter can compress nearby vessels, compromising cerebral blood flow, which can lead to an ischemic stroke. Ischemic strokes generally occur due to atherogenic or embolic phenomenon, albeit a rare etiology can be due to a mechanical obstruction of great vessels of the neck that provide blood supply to the brain.

Feasibility and Safety of Taxane-PIPAC in Patients with Peritoneal Malignancies-a Retrospective Bi-institutional Study.

Taxanes have a favorable pharmacokinetic profile for intraperitoneal application. We report our initial experience with taxane-PIPAC (pressurized intraperitoneal chemotherapy) for unresectable peritoneal metastases from different primary sites in terms of safety, feasibility, response rate, and conversion to resectability. In this retrospective study, PIPAC was performed alone or in combination with systemic chemotherapy.

Airway management, procedural data, and in-hospital mortality records of patients undergoing surgery for mucormycosis associated with coronavirus disease (COVID-19).

Purpose: Although unexpected airway difficulties are reported in patients with mucormycosis, the literature on airway management in patients with mucormycosis associated with Coronavirus disease is sparse.

Methods: In this retrospective case record review of 57 patients who underwent surgery for mucormycosis associated with coronavirus disease, we aimed to evaluate the demographics, airway management, procedural data, and in-hospital mortality records.

Results: Forty-one (71.

Process engineering strategy for large scale outdoor cultivation of Tetradesmus obliquus CT02 coupled with pH guided CO feeding.

A novel CO tolerant microalga Tetradesmus obliquus CT02, was previously evaluated to be a suitable bio refinery platform for synthesis of bioactive molecules, biodiesel, and biofertilizer. In the present study, a process engineering strategy was developed targeting improved growth performance of the strain at large scale under fluctuating outdoor environmental conditions. The strategy relies on maintaining pH of the culture at its optimal value via cascade control with CO feeding.

Proline confers acid stress tolerance to Bacillus megaterium G18.

Proline plays a multifunctional role in several organisms including bacteria in conferring protection under stress conditions. In this paper we report the role of proline in conferring acid tolerance to Bacillus megaterium G18. An acid susceptible mutant of B.

Identification of Putative Vaccine and Drug Targets against the Methicillin-Resistant by Reverse Vaccinology and Subtractive Genomics Approaches.

Methicillin-resistant (MRSA) is an opportunistic pathogen and responsible for causing life-threatening infections. The emergence of hypervirulent and multidrug-resistant (MDR) strains led to challenging issues in antibiotic therapy. Consequently, the morbidity and mortality rates caused by infections have a substantial impact on health concerns.

Estimating the economic cost of setting up a nuclear power plant at Rooppur in Bangladesh.

Bangladesh government is in the final stage of setting up one nuclear power plant with two units at Rooppur, Ishwardi, each having 1200 MW capacity, to be launched in 2023 to meet the energy shortage urgently. The financial cost of the project is the US $12.65 billion.

Acid tolerant bacterium Bacillus amyloliquefaciens MBNC retains biocontrol efficiency against fungal phytopathogens in low pH.

Soil pH conditions have important consequences for microbial community structure, their dynamics, ecosystem processes, and interactions with plants. Low soil pH affects the growth and functional activity of bacterial biocontrol agents which may experience a paradigm shift in their ability to act antagonistically against fungal phytopathogens. In this study, the antifungal activity of an acid-tolerant soil bacterium Bacillus amyloliquefaciens MBNC was evaluated under low pH and compared to its activity in neutral pH conditions.

Do Old Age and Comorbidity Non-Communicable Diseases Matter for COVID-19 Mortality? A Path Analysis.

This paper used Our World data for coronavirus disease-2019 (COVID-19) death count, test data, stringency, and transmission count and prepared a path model for COVID-19 deaths. We augmented the model with age structure-related variables and comorbidity non-communicable diseases for 117 countries of the world for September 23, 2021, on a cross-section basis. A broad-based global quantitative study incorporating these two prominent channels with regional variation was unavailable in the existing literature.

Melanin production and laccase mediated oxidative stress alleviation during fungal-fungal interaction among basidiomycete fungi.

Fungal-fungal interaction often leads to the change in metabolite profile of both the interacting fungus which may have potential implication in industry or agriculture. In the present study, we performed two sets of fungal-fungal interaction-Trametes coccinea (F3) with Leiotrametes lactinea (F9) and T. coccinea (F3) with T.

Simulation and Skill Training Facilities in Nursing Institutes at Uttarakhand: A Cross-Sectional Study.

Background: Simulation and skill development facilities are essential for the training and preparation of nursing students, which aids in their clinical readiness and professional development. The aim of the study was to assess simulation and skill training facilities, their utility in selected nursing institutes at Uttarakhand.

Materials And Methods: This descriptive cross-sectional study was conducted in conveniently selected 16 nursing institutes at Uttarakhand (India).

Introgression of Bacterial Blight Resistance Genes in the Rice Cultivar Ciherang: Response against pv. in the F Generation.

Bacterial blight (BB) is caused by pv. and is one of the most important diseases in rice. It results in significantly reduced productivity throughout all rice-growing regions of the world.

Two-stage integrated process for bio-methanol production coupled with methane and carbon dioxide sequestration: Kinetic modelling and experimental validation.

The study demonstrates a two-stage integrated process for bio-methanol production using Methylosinus trichosporium NCIMB 11131, coupled with sequestration of methane and carbon dioxide. The first stage involved generation of methanotrophic biomass via sequestration of methane; which was used as biocatalyst to reduce carbon dioxide into methanol in the second stage. Maximum biomass titer of 3.