Design and Implementation of a Dashboard for Drug Interactions Mediated by Cytochromes Using a Health Care Data Warehouse in a University Hospital Center: Development Study.

Background: The enzymatic system of cytochrome P450 (CYP450) is a group of enzymes involved in the metabolism of drugs present in the liver. Literature records instances of underdosing of drugs due to the concurrent administration of another drug that strongly induces the same cytochrome for which the first drug is a substrate and overdosing due to strong inhibition. IT solutions have been proposed to raise awareness among prescribers to mitigate these interactions.

Development and Validation of a Novel Human-Fixed Cadaveric Model Reproducing Cerebrospinal Fluid Circulation for Simulation of Endoscopic Endonasal Skull Base Surgery.

Background And Objectives: Endoscopic endonasal surgery is a well-established surgical approach to the skull base. Surgeons need a reusable long-lasting tool to acquire the skills needed for skull base reconstruction. The aim of this study was to elaborate and validate a human formalin-fixed cadaveric model that reproduces a realistic cerebrospinal fluid (CSF) circulation and that adequately renders a CSF leak.

Quality of Life After Head and Neck Cancer Surgery and Free Flap Reconstruction: A Systematic Review.

Background: Different factors can affect the quality of life of patients treated for head and neck cancer undergoing major surgical intervention. However, it remains unclear which specific factors and what possible interventions could have the greatest influence on quality of life postoperatively for patients undergoing surgical resection with free flap reconstruction. The objective of our systematic review was to identify which factors, at the time of surgical treatment, are associated with a worse postoperative quality of life for patients undergoing surgical resection with free flap reconstruction for head and neck cancer.

Direct tumoral puncture embolization of onyx before endoscopic endonasal resection of a massive juvenile angiofibroma for a patient with Von Willebrand disease - A case report and review of literature.

Introduction: Standard treatment of a juvenile angiofibroma (JNA) is surgical resection, usually with an endoscopic endonasal surgery and a preoperative embolization. However, standard intra-arterial embolization may fail to completely devascularize tumors. A novel technique of direct intranasal intratumoral onyx embolization has been described.

Home-Based Resistance Training Programme in Fontan Patients: It Is Feasible, Safe, and Efficient.

Background: Fontan physiology is characterized by a single functional systemic ventricle that reduces cardiac output adaptation and exercise capacity. Peripheral muscle pump is crucial for venous return, and resistance training of the peripheral muscles may be particularly beneficial for cardiac function in these patients. This study explores the feasibility of a training programme including safety and effectiveness, maximal exercise capacity, cardiorespiratory endurance, and quality of life in a Fontan population.

Trends in computerized provider order entry: 20-year bibliometric overview.

Background: Drug-related problems (DRPs) can lead to serious health issues and have significant economic impacts on healthcare systems. One solution to address this issue is the use of computerized physician order entry systems (CPOE), which can help prevent DRPs by reducing the risk of medication errors.

Objective: The purpose of this study is to provide an analysis on scientific production of the past 20 years in order to describe trends in academic publishing on CPOE and to identify the major topics as well as the predominant actors (journals, countries) involved in this field.

Language athletes: Dual-language code-switchers exhibit inhibitory control advantages.

Recent studies have begun to examine bilingual cognition from more nuanced, experienced-based perspectives. The present study adds to this body of work by investigating the potential impact of code-switching on bilinguals' inhibitory control abilities. Crucially, our bilingual participants originated from a predominantly dual-language environment, the interactional context which is believed to require (and therefore, potentially train) cognitive control processes related to goal-monitoring and inhibition.

Integrating a new knowledge organisation system for monoclonal antibodies for therapeutic use authorised in Europe into HeTOP terminology-ontology server.

Monoclonal antibodies (MAs) are increasingly used in the therapeutic arsenal. Clinical Data Warehouses (CDWs) offer unprecedented opportunities for research on real-word data. The objective of this work is to develop a knowledge organization system on MAs for therapeutic use (MATUs) applicable in Europe to query CDWs from a multi-terminology server (HeTOP).

Modeling and integrating interactions involving the CYP450 enzyme system in a multi-terminology server: Contribution to information extraction from a clinical data warehouse.

Introduction: The cytochrome P450 (CYP450) enzyme system is involved in the metabolism of certain drugs and is responsible for most drug interactions. These interactions result in either an enzymatic inhibition or an enzymatic induction mechanism that has an impact on the therapeutic management of patients. Detecting these drug interactions will allow for better predictability in therapeutic response.

Use of tramadol and the risk of bleeding complications in patients on oral anticoagulants: a systematic review and meta-analysis.

Purpose: This systematic review and meta-analysis aimed to determine whether tramadol intake increases the risk of bleeding in patients receiving oral anticoagulants.

Methods: This systematic review was registered on PROSPERO, CRD42022327230. We searched PubMed and Embase up to 14 April 2022, and references and citations of included studies were screened.

When A Nonnative Accent Lets You Spot All the Errors: Examining the Syntactic Interlanguage Benefit.

In our continuously globalizing world, cross-cultural and cross-linguistic communications are far from exceptional. A wealth of research has indicated that the processing of nonnative-accented speech can be challenging for native listeners, both at the level of phonology. However, few online studies have examined the underpinnings of accented speech recognition from the perspective of the nonnative listener, even though behavioral studies indicate that accented input may be easier to process for such individuals (i.

Impacts of the COVID-19 lockdown on energy consumption in a Canadian social housing building.

The COVID-19 pandemic hit societies in full force in 2020 and compelled people all around the world to change their lifestyle. The time spent at home significantly surged during the pandemic and this change in occupancy can have a direct impact on building energy consumption. COVID-19 lockdowns also accelerated the transition towards telework, a trend that many expect to last.

Role of depleted initial energy reserves in early benthic phase mortality of six marine invertebrate species.

Insufficient energy reserves are widely considered to be a primary factor contributing to high rates of early benthic phase mortality among benthic marine invertebrates, but this hypothesis has been based mostly on indirect, observational evidence, and remains largely untested. We therefore examined the role of initial energy reserves in regulating survivorship and growth during the early benthic phase. Recently settled or hatched individuals of six invertebrate species were collected from natural populations, maintained without food, and their survivorship was monitored.

Lexical-semantic processing costs are not inherent to intra-sentential code-switching: The role of switching habits.

A bank of past electrophysiological research suggests that code-switching (i.e., the use of multiple languages during a single conversational event) is characterized by increased processing costs.

A founder mutation in the gene in families from Saguenay-Lac-St-Jean region affected by a pyridoxine-dependent epilepsy.

Pyridoxine-dependent epilepsy (PDE) is a relatively rare subgroup of epileptic disorders. They generally present in infancy as an early onset epileptic encephalopathy or seizures, refractory to standard treatments, with rapid and variable responses to vitamin B6 treatment. Whole exome sequencing of three unrelated families identified homozygous pathogenic mutation c.

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Background: Artificial intelligence (AI) can be described as an advanced technology in which machines display a certain form of intelligence.

Objectives: The primary objective was to perform a narrative review of studies evaluating the feasibility and impact of AI in pharmacy. The secondary objective was to create a mind map of AI in health care.

Implications of acute temperature and salinity tolerance thresholds for the persistence of intertidal invertebrate populations experiencing climate change.

To predict whether populations of marine animals will persist in the face of changing climate conditions, it is informative to understand how past climate conditions have shaped present-day tolerance thresholds. We examined 4 species of intertidal invertebrates ( and ) inhabiting the coasts of Vancouver Island, Canada, where the east coast experiences historically warmer sea surface temperature (SST), warmer low tide (i.e.

Reliability and validity of the usability scale for assistive technology for computer access: a preliminary study using video-based evaluation.

: The focus of this research was to establish the interrater reliability and content validity of the Usability Scale for Assistive Technology-Computer Access (USAT-CA), an evaluation tool to facilitate selection of computer access AT devices for individuals with disabilities.: AT providers used the USAT-CA to evaluate two clients with physical disabilities interacting with their computer. Initially, an expert cohort of six providers used a draft version of the USAT-CA and provided feedback.

Metabolic effects of α-lipoic acid supplementation in pre-diabetics: a randomized, placebo-controlled pilot study.

Supplementation of health promoting nutraceuticals may be an effective adjunct strategy with other lifestyle and drug approaches to impede disease progression in prediabetic subjects. α-Lipoic acid, a naturally occurring short-chain fatty acid, has been extensively evaluated for its antioxidant and glycemic control properties but has rarely been investigated as a lipid-lowering strategy. We conducted a pilot study to examine the effects of α-lipoic acid supplementation on glycemic control and lipid profile in pre-diabetic, overweight/obese adults.

Food safety considerations for commercial complementary foods from global operational guidance on infant and young child feeding in emergencies.

The use of commercial complementary food (CCF) in humanitarian emergencies is an emerging topic in nutrition policy. Food safety guidance is helpful for the prevention of foodborne illnesses in infants and young children, but whether current global operational guidance on infant and young child feeding in emergencies (IYCF-E) adequately addresses food safety for CCF in humanitarian emergencies is unknown. The aim of this review was to identify and synthesize available food safety guidance on the use of CCF in humanitarian emergencies.

Antibacterial properties of the pituitary adenylate cyclase-activating polypeptide: A new human antimicrobial peptide.

The Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP), a polycationic, amphiphilic and helical neuropeptide, is well known for its neuroprotective actions and cell penetrating properties. In the present study, we evaluated the potent antibacterial property of PACAP38 and related analogs against various bacterial strains. Interestingly, PACAP38 and related analogs can inhibit the growth of various bacteria including Escherichia coli (JM109), Bacillus subtilis (PY79), and the pathogenic Burkholderia cenocepacia (J2315).

Use of Virtual Technology as an Intervention for Wheelchair Skills Training: A Systematic Review.

Objective: To provide a comprehensive description of the current state of knowledge regarding the use of virtual technology (VT) for wheelchair skills training.

Data Sources: The Cochrane Library, MEDLINE, CINAHL, Embase, ACM, IEEE Xplore, Inspec, and Web of Science databases were searched for relevant articles from 1990 to February 2016.

Study Selection: We included peer-reviewed studies or long conference proceedings that examined the use of VT as a medium to provide a wheelchair skills training intervention for any population with any diagnosis using any research design.

Effect of an Acute Bout of Kettlebell Exercise on Glucose Tolerance in Sedentary Men: A Preliminary Study.

Impaired glucose tolerance can have significant health consequences. The purposes of this preliminary study were to examine whether a single session of kettlebell exercise improves acute post-exercise glucose tolerance in sedentary individuals, and whether it was as effective as high-intensity interval running. Six sedentary male subjects underwent a two-hour oral glucose tolerance test following three different conditions: 1) control (no exercise); 2) kettlebell exercise (2 sets of 7 exercises, 15 repetitions per exercise with 30 seconds rest between each exercise); or 3) high-intensity interval running (10 one-minute intervals at a workload corresponding to 90% VOmax interspersed with one-minute active recovery periods).