Publications by authors named "Gorozhanin A"

Article Synopsis
  • - Surgical treatment for peripheral nerve injuries only works effectively about 50% of the time, mainly due to issues like gaps between nerve fragments and complications from using autografts, which can lead to scar tissue and mismatch in sizes.
  • - A recent study demonstrated a successful case of multifascicular ulnar nerve autoplasty using biodegradable materials (SpheroGel and ElastoPob) and a revascularization technique that involved a connective tissue flap.
  • - Post-surgery, patients experienced significant relief from pain and ultrasound results showed successful nerve regeneration without neuroma formation, alongside positive improvements in pain and function as measured by various questionnaires.
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Unlabelled: According to the literature, recurrent disc herniation of the lumbar spine occurs in 5-10% of cases. Objective. To develop an algorithm for surgical treatment of recurrent lumbar spine disc herniation based on analysis of risk factors of relapse and assessment of intra- and postoperative period.

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Article Synopsis
  • This study investigates how genetic factors contribute to degenerative disc disease by reviewing existing literature from 2002 to 2022.
  • A total of 84 references were examined, with 43 significant studies selected for detailed analysis after excluding duplicates and less relevant publications.
  • Findings indicate that while there is some data on various biological processes involved in the disease, the involvement of genetic regulation remains limited, with certain factors like microRNA and TGF-b needing further research.
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Objective: To describe the features of diagnosis and surgical treatment of thoracic spine fracture in a patient with ankylosing spondylitis.

Material And Methods: We present a patient with ankylosing spondylitis, blunt thoracic spine trauma and Th10-Th11 fracture, spinal cord compression and contusion and moderate lower extremity paresis. Preoperative and postoperative CT and MRI (after 8 months) were performed for control of decompression.

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Article Synopsis
  • Alkaptonuria is a rare genetic disorder where the body cannot properly metabolize homogentisic acid, leading to the buildup of melanin-like pigments in connective tissues.
  • The condition often results in spine issues, particularly affecting the lumbar region, similar to other degenerative spine diseases.
  • A case study of a 67-year-old patient showed severe compression of the cauda equina caused by cartilage damage and pigment deposits, which was confirmed through surgery and histological examination.
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At the elbow, the ulnar nerve may be compressed either in the retrocondylar groove, in the cubital tunnel, or compressed by Osborne's band. Optimal surgical therapy should be directed at the specific site of involvement. It is more difficult to identify the level of ulnar nerve compression.

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On the basis of analysis of presentation and surgical treatment of 103 patients with lumbar disc herniation the authors performed comparative assessment of symptoms and therapeutic techniques in patients with higher and lower lumbar disc disease. Short-term and long-term results were evaluated using visual analogue scale and Oswestry disability index (ODI). Statistically significant differences in dynamics of pain and ODI were not present.

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Primary CNS tumors represent 1.4% of all malignant neoplasias and 2.4% of total oncological mortality.

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The paper provides the results of studies of the effects produced by the new vasoactive agent Dimephosphone, which normalizes the function of the nervous system, on the performance of the regulatory mechanisms responsible for the circulatory provision of chemical and physical homeostasis of the brain in patients with cerebral neoplasms. A five-day course of Dimephosphone monotherapy was demonstrated to normalize the cerebral circulatory regulatory system in the preoperative period. Preoperative Dimephosphone normalization of the regulatory mechanisms of cerebral circulatory provision ensures the tolerance of the cerebral circulatory system to intraoperative injury.

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The paper gives the results of experimental and clinical studies of the nootropic agents dimephosphone, sermion, and piracetam on local cerebral circulation, cerebrovascular responsiveness and O2 tension. The vasoactivity of the parameters studied has been shown to be displayed by their ability to normalize cerebrovascular responsiveness and it is associated with decreased brain tissue oxygen consumption when dimephosphone is applied and with its increased one when sermion and piracetam are used.

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The authors suggest the principles of evaluation of the condition of the system regulating the circulatory provision of cerebral physical and chemical homeostasis, as well as a measurement complex and a set of instrumentally recorded values for control over the cerebral arteries' and veins' response to unified loads of physical and chemical nature in patients with neurosurgical pathology. The scientific and practical significance of such an approach to evaluation of cerebral blood circulation is reasoned by the results of accumulated experience in controlling the activity of some regulations of circulatory provision of the brain in healthy females and males differing in age and in 114 patients with brain tumors.

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