Clinical course and outcome of patients with ACTH-dependent Cushing's syndrome infected with novel coronavirus disease-19 (COVID-19): case presentations.

Objective: To analyze the clinical presentations of patients with endogenous Cushing's syndrome (CS) affected by Coronavirus disease-19 (COVID-19).

Materials And Methods: Patients who were referred to our clinic with active CS from 31st March to 15th May 2020 were screened for COVID-19 using real-time reverse transcriptase-polymerase chain reaction (RT-PCR). Late-night serum cortisol (64-327 nmol/L), late-night salivary cortisol (LNSC) (0.

A new tool CovReport generates easy-to-understand sequencing coverage summary for diagnostic reports.

In order to properly interpret the results of a diagnostic gene panel sequencing test, gene coverage needs to be taken into consideration. If coverage is too low, an additional re-sequencing test is needed to make sure that a pathogenic variant is not missed. To facilitate the interpretation of coverage data, we designed CovReport, a novel easy-to-use visualization tool.

Effectiveness of one-stage microdiscectomy and radiofrequency denervation of intervertebral joints compared to microdiscectomy in patients with spinal disc herniation.

The article analyzes of the early and long-term outcomes in 113 patients who underwent surgical treatment for lumbosacral disc herniations. The first group of patients (n=32) underwent microdiscectomy in a combination with radiofrequency destruction (RFD) of the facet nerves. The control group patients (n=81) underwent microdiscectomy.

The sequence of the human genome.

A 2.91-billion base pair (bp) consensus sequence of the euchromatic portion of the human genome was generated by the whole-genome shotgun sequencing method. The 14.

[Recurrent urethrorectal fistulae].

On the basis of 32 surgical cases of recurrent urorectal fistulas, review of relevant literature, the authors define factors determining choice of treatment and preoperative preparation policy. Such individual approach may secure success in many cases. A new surgical procedure of surgical treatment of urethrorectal fistulas involving abdominoanal resection of the rectum with implantation of the sigmoid into the anus has been tried and found satisfactory.

[The ultrasonic diagnosis of diseases of the urethra in women].

Ultrasonic examinations of the urethra were carried out in 188 women suffering from dysuria, making use of transducers for transcutaneous and transvaginal scanning. The authors describe in detail the echographic picture of the urethra in health and in various diseases, e.g.

[Strictures of the proximal urethra in men].

Stricture of proximal male urethra remains complicated problem of urology. Surgical intervention conducted at sphincter area is fraught with the damage of potential enuresis. A total of 250 patients with proximal urethra strictures were treated.

[Postinflammatory strictures of the urethral canal in women].

The paper is concerned with one of the important problems of current urology--inflammation-induced strictures of the female urethra, covers questions of its etiology, pathogenesis, clinical patterns, diagnosis and treatment. It is emphasized that the strictures take the form of paraurethral fibrosis and should be managed individually. Clinicomorphological parallels are outlined.

[A comparative evaluation of surgical methods for treating hydrocele].

The authors analysed the results of the surgical treatment of 167 patients with hydrocele who were operated on with the use of Winkelmann's or Bergmann's technique (group I), the same but modified by Grebenshchikov-Shevtsov's (group II), and Lord's method (group III). Sclerotherapy was employed in the group IV patients. A high percentage of complications was associated with Winkelmann and Bergmann's techniques (scrotal edema, hematoma, wound purulence) when the hydropic sac was isolated from the adjacent tissues.