[Active chronic gastritis and Helicobacter pylori].

Biopsies from fundal and pyloric regions of the stomach of 140 patients with histologic signs of active chronic gastritis (ACG) are studied. Two types of ACG are distinguished: associated with HP and HP-negative. Inflammatory reaction in the foveal epithelium and lamina propria of the mucous membrane is characteristic for the ACG of the former type.

[The experimental and clinical effect of ciprofloxacin on the microflora of the gastrointestinal tract].

The study of the influence of cyprofloxacin on the microflora of the gastrointestinal tract has been made under experimental and clinical conditions. As revealed in this study, cyprofloxacin produces a corrective effect on the intestinal microflora; the action of this preparation, in contrast to that of other antimicrobial preparations, is retained for a long time. In patients having duodenal ulcer with bacteriosis caused by Campylobacter pylori and with intestinal dysbacteriosis the combination of cyprofloxacin and cimetidine yields a higher therapeutic effect than the use of cimetidine alone.

[Assessment of the efficacy of de-nol and bismuth subnitrate treatment of patients with associated peptic ulcer and pyloric Helicobacter infection (experimental and clinical studies)].

The duration of colloid bismuth subcitrate (de-nol) and bismuth subnitrate (BSN) fixation on the mucosa was studied in animal experiments and in patients suffering from peptic ulcer using scanning electron microscopy and roentgenospectral analysis. In patients suffering from peptic ulcer with pyloric chelicobacter (PC), a study was made of the relationship between the duration of bismuth drugs fixation on the mucosa and the degree of PC elimination as well as of the therapeutic efficacy in such patients of the use of de-nol and BSN. The characteristic features of the structure of de-nol granules were defined, enabling those granules to be fixed on the mucosa for more than 12 hours.

[Secretory immunoglobulin A and pyloric helicobacteriosis in patients with duodenal ulcer].

57 patients with duodenum ulcer were examined. Secretory immunoglobulin A (SIgA) was determined by an immunofluorescent method in the gastric and duodenum mucosa depending on the population size of pyloric helicobacter (HB). The frequency of SIgA detection in the gastric mucosa depends on the HB population size: when it is considerable SIgA was not detected in 41% cases.

[State of local and total humoral immunity in duodenal ulcer with Campylobacter pylori infection].

A total of 83 patients with duodenal ulcer and a varying degree of gastric mucosa contamination with C. pylori were examined. Secretory IgA was less frequently detectable in the gastric juice of patients with higher level of gastric mucosa contamination with C.

[Apoptosis and regeneration of the gastric mucosa under the action of S-phase-specific agent, hydroxyurea].

The treatment of periodic injections of hydroxyurea to mice on the processes of regeneration in gastric mucosa was studied. In all experimental groups of animals dystrophic and atrophic changes of gastric mucosa could be observed. The phenomena of dystrophy were more pronounced.

[Fibrinoid and fibrinoid necrosis in the morphogenesis of chronic stomach ulcers (electron and light microscopy)].

The stomach surgically removed from 38 patients because of chronic ulcers are studied. The fibrinoid necrosis zone observed at the bottom of 30 ulcers is formed of two layers out of which the superficial layer only is necrotic while the deep one represent a fibrinoid swelling. The latter consists of the network of collagen fibers and fibrin elements with surviving connective tissue cells.

[The resonance nature of the dependence of epithelial lesions of the small intestine in mice on the interval between injections of an S-phase-specific agent--hydroxyurea].

The dependence of the injury of murine small intestinal epithelium on the interval between multiple regular injections of hydroxyurea (HU) was investigated. Mice were injected 8 times with HU (5 mg per injection) in different experimental groups of animals, and the interval between injections varied from 6 to 19 hours. With the intervals between the injections close to 8 or 16.

[Significance of the intervals of hydroxyurea administration for epithelial damage to the small intestine in mice].

The states of the murine small intestinal epithelium 6, 30 and 78 h after the end of the multiple regular injections of hydroxyurea (HU) were analysed with the aid of the light and electron microscopy. The course of 6 regular injections of 5 mg/mouse HU was begun 24 h after the initiating gamma-irradiation in a dose 200 rad and the interval between injections was varied from 7 to 19 h for different experimental groups of mice. The analysis of the epithelial state revealed two minima of the tissue damage which correspond to the courses of HU injections with the intervals close 9 h and 16.

[Apoptosis and regeneration of enterocytes in experimental atrophy of the small intestine mucosa].

Apoptosis, one of the types of cell deaths, participates in regulating the size of regenerated tissue. Severe atrophy of small intestine mucosa in mice was caused by the administration of hydroxyurea solution. The degree of atrophy correlated with a lowering mitotic activity and DNA synthesis in the epithelium of crypts.

[G1 and G2 chalones of the gastric mucosa].

A study was made of the action of human gastric mucosa G1 and G2 chalones on cellular regeneration of mouse gastric mucosa and of the duration of their maximal effect. Chalone fractions were obtained from the mucous membranes of 21 stomachs resected for peptic ulcer by the method of fractional ethanol precipitation. The data indicate that the maximal inhibitory action of G1 chalone occurs in 3, whereas that of chalone G2 in 6 hours.

[Certain Mechanisms regulating cell renewal in the gastric mucosa in peptic ulcer].

A study was made of the effect of an aqueous extract of human gastric mucosa on the mitotic activity of the surface epithelium of the mouse stomach. The extract was found to exert a statistically significant inhibitory action. An extract from the mucosa of the stomach resected for duodenal ulcer exerted a more pronounced inhibitory action as compared with an extract from the stomach resected for gastric ulcer.

[Structure and histochemical characteristics of the mucosa of the Vater's ampulla in man (according to materials of aimed biopsies)].

Examination of 52 aimed duodenal biopsies has revealed that there are several variants of the structure of the Vater's papilla mucous membrane. In a number of cases it is identicalto the mucous membrane of the duodenum. In 20 cases the Vater's papilla was covered with mucoid epithelium which was histochemically similar to the epithelium lining the stomach, bile ducts and the gallbladder.