Subclinical thyroid disease: scientific review and guidelines for diagnosis and management.

Context: Patients with serum thyroid-stimulating hormone (TSH) levels outside the reference range and levels of free thyroxine (FT4) and triiodothyronine (T3) within the reference range are common in clinical practice. The necessity for further evaluation, possible treatment, and the urgency of treatment have not been clearly established.

Objectives: To define subclinical thyroid disease, review its epidemiology, recommend an appropriate evaluation, explore the risks and benefits of treatment and consequences of nontreatment, and determine whether population-based screening is warranted.

Attenuating negative differential resistance in an electroactive self-assembled monolayer-based junction.

The negative differential resistance (NDR) peak current observed in redox active self-assembled monolayer-based molecular junctions has been attenuated by controlling the composition of the molecular junction. Two approaches studied here include capping the electroactive ferrocenyl groups with beta-cyclodextrin and functionalizing the scanning tunneling microscope tip used to probe the self-assembled monolayer (SAM) with n-alkanethiols of different lengths. These are the first examples of systematic modification of the magnitude of the NDR response in a molecule-based system.

Synthetic approaches to an isostructural series of redox-active, metal tris(bipyridine) core dendrimers.

Several types of six-armed, metal tris(bipyridine) core dendrimers were synthesized. Bis-4,4'-alkoxy bipyridine dendrons were prepared and employed to make tris(bipyridine) dendrimers. Although the ruthenium-centered and iron-centered dendrimers displayed quasi-reversible cyclic voltammetry, the analogous cobalt-centered complex did not.

Optic neuropathy of Graves disease: results of transantral orbital decompression and long-term follow-up in 215 patients.

Purpose: To review demographic characteristics, clinical features, and long-term outcomes of patients with optic neuropathy of Graves disease after transantral orbital decompression.

Design: Retrospective analysis of noncomparative interventional case series; long-term follow-up by questionnaire.

Methods: Medical record data (preoperative and postoperative assessments) were collected from patients who had transantral orbital decompression to treat Graves optic neuropathy.

Haemoglobin Etobicoke, an incidental finding in an Irish diabetic.

It is well recognized that haemoglobin variants can be detected during the measurement of HbA1c by high-performance liquid chromatography (HPLC). A number of variants have been reported as compromising the quantification of HbA1c, a marker used in the assessment of glycaemic control in diabetes. We describe a case of haemoglobin Etobicoke, a rare alpha chain variant detected in an Irish diabetic during HbA1c analysis.

Structural effects on encapsulation as probed in redox-active core dendrimer isomers.

Three pairs of isomeric, iron-sulfur core dendrimers were prepared. Each isomer pair was distinguished by a 3,5-aromatic substitution pattern (extended) versus 2,6-aromatic substitution pattern (backfolded). Several observations were made that supported the hypothesis that the iron-sulfur cluster cores were encapsulated more effectively in the backfolded isomers as compared to their extended isomeric counterparts.

Retinal microvascular abnormalities in patients treated with external radiation for graves ophthalmopathy.

Background: A prospective study was conducted to determine if external ionizing radiation could favorably influence the orbital manifestations of Graves ophthalmopathy. Diabetes and untreated systemic hypertension were exclusion criteria. Radiation was directed to the orbits of 42 affected patients using 0.

Heat-pressed ionomer glass-ceramics. Part I: an investigation of flow and microstructure.

Objectives: This study investigated a series of ionomer glasses based on the formula: 4.5SiO(2)-1.5P(2)O(5-)(X)Al(2)O(3)-4.

Orbital radiotherapy for Graves' ophthalmopathy: useful or useless? Safe or dangerous?

Treatment of Graves' ophthalmopathy does not always provide favorable results. After several decades of efforts, glucocorticoids, orbital radiotherapy (OR) and surgery (orbital decompression) remain the milestones in the management of this disease. OR produce favorable results in about 55-60% of patients.