Ocular Effects of Prenatal Carotenoid Supplementation in the Mother and Her Child: The Lutein and Zeaxanthin in Pregnancy (L-ZIP) Randomized Trial - Report Number 2.

Purpose: Lutein (L) and zeaxanthin (Z) are xanthophyll carotenoids that have been promoted to enhance maternal health and infant visual and neurodevelopment. In this study, we determined the effects of prenatal L and Z supplementation on systemic and ocular carotenoid status in the mother and her newborn infant (NCT03750968). This report focuses on the ocular effects of prenatal carotenoid supplementation.

Research on the Influence of HMFI and PWHT Treatments on the Properties and Stress States of MAG-Welded S690QL Steel Joints.

The aim of this study was to analyze the effect of the HFMI (high-frequency mechanical impact) treatment of each weld bead on the properties of a butt joint with a ceramic backing welded by robotic method 135 (MAG-metal active gas welding method) and to determine the effect of HMFI on the stress level. This analysis was based on a comparison of three butt joints made of a S690QL plate, in the as-welded condition, with the HFMI of each bead and with the heat treatment carried out with PWHT stress relief annealing. The high-frequency (90 Hz) peening of each weld bead was linked with a stress reduction in the weld via the implementation of compressive stresses into the joint.

Microstructure and Erosion Wear of In Situ TiC-Reinforced Co-Cr-W-C (Stellite 6) Laser-Cladded Coatings.

The article presents research results on the possibility of shaping the structure and properties of Co-Cr-W-C-Ti alloys (type Stellite 6) using laser cladding technology. Cobalt-based alloys are used in several industries because they are characterized by high erosion, abrasion, and corrosion resistance, retaining these properties at high temperatures. To further increase erosion resistance, it seems appropriate to reinforce material by in situ synthesis of hard phases.

Virtual Sensor for On-Line Hardness Assessment in TIG Welding of Inconel 600 Alloy Thin Plates.

Maintaining high-quality welded connections is crucial in many industries. One of the challenges is assessing the mechanical properties of a joint during its production phase. Currently, in industrial practice, this occurs through NDT (non-destructive testing) conducted after the production process.

Effect of Cooling Rate on Microstructure of In Situ TiC-Reinforced Composite Surface Layers Synthesized on Ductile Cast Iron by Laser Alloying.

The microstructure of the in situ TiC-reinforced composite surface layers developed during laser surface alloying of a ductile cast iron substrate with titanium was related to the solidification conditions in the molten pool. The solidification conditions were estimated using infrared thermography. It was found that the cooling rates of the melt up to about 700 °C/s enable the complete reaction between carbon and the entire amount of titanium introduced into the molten pool.

Mortality and major postoperative complications within 1 year after vascular surgery: a prospective cohort study.

Introduction: Patients undergoing vascular procedures are prone to developing postoperative complications affecting their short‑term mortality. Prospective reports describing the incidence of long‑term complications after vascular surgery are lacking.

Objectives: We aimed to describe the incidence of complications 1 year after vascular surgery and to evaluate an association between myocardial injury after noncardiac surgery (MINS) and 1‑year mortality.

Systemic Effects of Prenatal Carotenoid Supplementation in the Mother and her Child: The Lutein and Zeaxanthin in Pregnancy (L-ZIP) Randomized Trial -Report Number 1.

Background: Adding carotenoids, particularly lutein (L) and zeaxanthin (Z), to prenatal micronutrient formulations has been promoted to enhance infant visual and neural development and to maintain maternal health. Although these claims are biologically plausible, they are not yet supported by a compelling prospective trial.

Objective: We investigated the effect of prenatal carotenoid supplementation on biomarkers of maternal and infant systemic carotenoid status.

Dynamic Range Compression of Thermograms for Assessment of Welded Joint Face Quality.

Temperature is one of the essential parameters in fusion welding. Typically, an uncooled infrared detector acquires 14-bit data, while a human observer can only distinguish about 128 levels of grey. For IR HDR (high dynamic range) images, one of the main goals of dynamic range compression is to enhance the visibility of low-contrast details.

The Structure and Properties of Laser-Cladded Inconel 625/TiC Composite Coatings.

This article presents production results concerning metal matrix composite-coatings made using the laser-cladding technology. The enhancement of the wear resistance of the material surface is the one of the main goals accompanying the manufacturing of composite coatings. Nickel-based superalloys are used in several industries because they are characterized by a number of desirable properties including high tensile and fatigue strength as well as resistance to high-temperature corrosion in aggressive environments.

The effect of TIG welding on the structure and hardness of butt joints made of Inconel 718.

The tests discussed in the article aimed to analyse the structure and hardness of the heat affected zone and that of the weld in thin butt joints (1.0 mm) made of Inconel 718 using the TIG method and variable welding linear energy restricted within the range of 45 J/mm to 80 J/mm. The test joints were subjected to visual tests, macro and microscopic metallographic tests, scanning electron microscopy-based structural observations and hardness measurements.

Assessment of the Laser Beam Welding of Galvanized Car Body Steel with an Additional Organic Protective Layer.

This study discusses the effect of laser beam welding parameters on the structure, mechanical properties and corrosion resistance of 1.2 mm thick galvanized sheets made of low-carbon steel DC04 provided with a ZE36/36 GardoprotectOC2BU organic coating. The test laser beam butt welded joints were made without the filler metal, using a variable welding rate, where linear welding energy was restricted within the range of 30 J/mm to 90 J/mm.

Resistance to tyrosine kinase inhibitors promotes renal cancer progression through MCPIP1 tumor-suppressor downregulation and c-Met activation.

Tyrosine kinase inhibitors (TKIs) are the most commonly used targeted therapeutics in clear-cell renal cell carcinoma (ccRCC); however, drug resistance limits their utility and can lead to tumor "flare-up" and progression. In this study, we show that RCC resistance to sunitinib and sorafenib involves different mechanisms and leads to increased malignancy. Sunitinib decreased tumor growth and cell motility along with increased E-cadherin expression and secretion of the proangiogenic cytokines IL6 and IL8, which activated senescence in ccRCC cells and led to VE-cadherin phosphorylation, enhancing tumor angiogenesis.

Treatment outcomes in Polish COVID-19 patients requiring hospitalisation in the intensive care unit: a single-centre retrospective study.

Introduction: COVID-19 has disturbed the functioning of Polish healthcare for the past two years. Due to the high proportion of patients requiring admission to the intensive care unit (ICU), these wards are particularly overwhelmed and are considered the bottleneck of the healthcare system. The aim of this study was to describe clinical outcomes of critically ill patients treated in a single tertiary ICU in Poland, assess factors associated with mortality and compare outcomes of patients treated during the 2nd and 3rd waves of the pandemic.

Short-term mortality of patients ≥80 years old admitted to European intensive care units: an international observational study.

Background: Limited evidence suggests variation in mortality of older critically ill adults across Europe. We aimed to investigate regional differences in mortality among very old ICU patients.

Methods: Multilevel analysis of two international prospective cohort studies.

Prognostic value of preoperative electrocardiography in predicting myocardial injury after vascular surgery.

Background: The current European guidelines recommend that a preoperative electrocardiogram (ECG) should be performed routinely in patients scheduled for high-risk surgery. However, the evidence regarding ECG as a predictor of perioperative cardiac complications is weak.

Aim: To evaluate the association of preoperative ECG with short- and long-term outcomes in patients undergoing high-risk vascular procedures.

High-Power Diode Laser Surface Transformation Hardening of Ferrous Alloys.

A high-power direct diode laser (HPDDL) having a rectangular beam with a top-hat intensity distribution was used to produce surface-hardened layers on a ferrous alloy. The thermal conditions in the hardened zone were estimated by using numerical simulations and infrared (IR) thermography and then referred to the thickness and microstructure of the hardened layers. The microstructural characteristics of the hardened layers were investigated using optical, scanning electron and transmission electron microscopy together with X-ray diffraction.

MCPIP1 regulates focal adhesion kinase and Rho GTPase-dependent migration in clear cell renal cell carcinoma.

Metastasis is responsible for as many as 90% of cancer-associated deaths in patients. The metastatic process is a result of tumor cell migration and invasion associated with morphological changes and increased expression of several genes involved in cell migration. We have already shown that monocyte chemotactic protein-1-induced protein-1 (MCPIP1), a negative regulator of inflammatory processes, influences cell morphology, prevents the epithelial to mesenchymal transition program, and regulates metastasis in clear cell renal cell carcinoma (ccRCC).

FEM-Based Thermogram Correction for Inconel 625 Joint Hardness Clustering.

Assessing the temperature of the joint in on-line mode is a vital task that is demanded to characterize the formations of terns formations that are taking place in a joint and result in reaching necessary properties of the joint. Arc welding generates a high amount of heat that is reflected by the metallic surface of the welded object. In the paper, a temperature measurement credibility increase method is described and evaluated.

MCPIP1 inhibits Wnt/β-catenin signaling pathway activity and modulates epithelial-mesenchymal transition during clear cell renal cell carcinoma progression by targeting miRNAs.

Epithelial-mesenchymal transition (EMT) refers to the acquisition of mesenchymal properties in cells participating in tumor progression. One hallmark of EMT is the increased level of active β-catenin, which can trigger the transcription of Wnt-specific genes responsible for the control of cell fate. We investigated how Monocyte Chemotactic Protein-1-Induced Protein-1 (MCPIP1), a negative regulator of inflammatory processes, affects EMT in a clear cell renal cell carcinoma (ccRCC) cell line, patient tumor tissues and a xenotransplant model.

Assessment of Airway Remodeling Using Endobronchial Ultrasound in Asthma-COPD Overlap.

Purpose: The aim of this study was to evaluate the structural changes of the airways using the endobronchial ultrasound (EBUS) in ACO patients compared to severe asthma and COPD patients.

Patients And Methods: The study included 17 patients with ACO, 17 patients with COPD and 33 patients with severe asthma. Detailed clinical data were obtained from all participants.

A clinical profile and factors associated with severity of the disease among Polish patients hospitalized due to COVID-19 - an observational study.

Introduction: The coronavirus disease 2019 (COVID-19) is one of the greatest clinical challenges of the last decades. Clinical factors associated with severity of the disease remain unclear. The aim of the study was to characterize Polish patients hospitalized due to COVID-19 and to evaluate potential prognostic factors of severe course of the disease.